Task Individual Differences in the Neurochemical and Behavioral Response to Exposure to Protons and HZE Particles (Completed)
Last Published:  07/30/20 02:45:15 PM (Central)
Short Title: HZE Individual CNS
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
  1. Evaluate the effects of repeated subthreshold exposures to HZE particles and protons on cognitive and neuronal deficits and how they relate to the characteristics of the specific particle.
  2. Determine the relationship between changes in performance and HZE particle- and proton-induced changes in oxidative stress, inflammation, signaling molecules and autophagy in key brain regions.
  3. Determine how individual characteristics, including age and sex, may influence the responsiveness of the individual to HZE particle irradiation.
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