Task The Role of the Bone Marrow Microenvironment in Space Radiation-Induced Leukemogenesis (Completed)
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: Microenvironment Leukemogenesis
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
We hypothesize that GCR and SPE radiation can have a deleterious impact not only at the level of the mature immune cells and their committed progenitors, as is currently thought, but at the earlier developmental stage of the HSC. Genetic lesions induced by this exposure can lead directly to leukemic transformation, and may also cause these cells to generate a functionally compromised immune system lacking the ability to effectively fight challenges such as pre-leukemic transformations. As such, astronauts would be doubly at risk, due to both the potential for induction of leukemia by GCR/SPE radiation, and the reduced ability of the astronauts’ immune systems to identify and eliminate malignant cells in the body. Since it has also been shown that both gender and genetic factors likely impact upon susceptibility to leukemogenesis, it is essential to precisely define these risks to the human hematopoietic system as a result of exposure to GCR/SPE and to accurately model the impact of gender and genetic/epigenetic background. Unfortunately, existing animal model systems have not allowed the precise assessment of the risks associated with acute or chronic exposure of human hematopoietic cells to GCR or SPE, nor the elucidation of the mechanism involved.
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Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here!TaskThe Role of the Bone Marrow Microenvironment in Space Radiation-Induced Leukemogenesis

RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
You are here!TaskThe Role of the Bone Marrow Microenvironment in Space Radiation-Induced Leukemogenesis

RiskRisk of Radiation Carcinogenesis
You are here!TaskThe Role of the Bone Marrow Microenvironment in Space Radiation-Induced Leukemogenesis