Task Mechanistic Study of the Risk of Low Doses of HZE Particles on Human Cell Pre-Malignant Transformation
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: HZE Transformation
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Terminated - A formerly active task that was stopped before its completion date due to deselection, descoping, reorganization etc.
Procurement Mechanism(s):
Solicited
Aims:
  1. Investigate how p63 promotes HZE particle-induced human epithelial cell transformation through the JAG1/Wnt4#Myc pathway.
  2. Investigate how p63 promotes HZE particle-induced human epithelial cell transformation through the CD95#JNK#Jun pathway.
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