Task Testing Mechanical Countermeasures for Cephalad Fluid Shifts [MECHANICAL COUNTERMEASURES - MARKETED DEVICES/STRANGMAN] (Completed)
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: Mechanical Countermeasures - Marketed Devices
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
National Space Biomedical Research Institute (NSBRI)
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:

The objective is to test two qualitatively distinct countermeasures (CMs) for VIIP, based on the

assumption that VIIP is caused—or influenced—by cephalad fluid shifts. Studies will be

conducted at MGH as well as at Baylor College of Medicine/NSBRI Center for Space Medicine.

Aim 1: Identify and characterize cerebrovascular and/or ophthalmological parameters altered

by cephalad fluid shifts that are mitigated by mechanical countermeasures.

Aim 2: Identify and characterize any rebound effects or other adverse occurrences when use of

the mechanical countermeasure device is discontinued.

Aim 3: Quantify the effect of two mechanical countermeasures on their ability to reduce

invasively-measured continuous ICP.

Aim 4: Determine if gradual CM discontinuation is safer than abrupt discontinuation.

Aim 5: Quantify the relationship between CM exposure time vs. ICP reduction (and rebound).

Mappings
RiskRisk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
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