HRR - Task - Immune Clinical Correlations

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Immune Clinical Correlations (Completed)

Last Published: 07/30/21 01:05:34 PM (Central)

Task Book: Entry Unavailable
Principal Investigator: Tyring, Stephen

Short Title: Immune Clinical Correlations

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Directed

Aims:

[1] Determine the patterns of immune dysregulation (innate + adaptive) and latent herpesvirus reactivation associated with clinical disease, including: bacterial/viral infections, autoimmunity, hypersensitivities and malignancies

[2] Determine the status of immune dysregulation from initial presentation through treatment/recovery for similar patient populations

[3] Analyze Terrestrial clinical data in conjunction with in-flight data to ascertain correlations and determine clinical relevance for in-flight immune dysregulation

Integration/Unique Aspects: TBD

Resources (Other)

Deliverables (1)

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:
This study will provide a report with clinical immune data for infectious disease, allergy, hypersensitivity, etc. This study will be operated out of NASA-JSC to allow live-cell assays to be performed. Overseas studies require a frozen sample, which precludes live-cell analysis for NASA assays. The report will contribute to gap closure by analyzing terrestrial clinical data in conjunction with in-flight data to ascertain correlations and determine clinical relevance for in-flight immune dysregulation. Upon completion, gap closure will be ~85%.

Internal Customers:
Human Health Countermeasures
External Customers:
None

Mappings

Risk of Adverse Health Event Due to Altered Immune Response

IM7: It is necessary to correlate the observed effects of spaceflight-associated immune system dysregulation with known terrestrial clinical conditions.

Immune Clinical Correlations

Related Tasks (53)

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Risk Approach Plans (1)

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Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response