Task Role of the Cranial Venous Circulation in Microgravity-Associated Visual Changes [CRANIAL VENOUS CIRCULATION/BUCKEY] (Completed)
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: Cranial Venous Circulation
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
National Space Biomedical Research Institute (NSBRI)
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:

1. Develop a numerical model to estimate changes in intracranial venous

flow, volume, compliance and pressure in response to a fluid shift and changes in

hydrostatic gradients. Include tissue compressive forces in the model.

2. Determine the cranial venous changes produced by fluid shifts and

altered hydrostatic gradients. Use interventions that can produce fluid shifts

(lower body negative pressure and lower body positive pressure) and alter

hydrostatic gradients (supine and prone postures). These experiments are

designed to provide data for validating and verifying the model developed as a

part of Aim #1.

3. Identify individuals with common intracranial venous variants, and study

them using the protocol outlined in Aim #2.

By building and validating a numerical model, we will be able to use the model to: (a)

develop hypotheses about spaceflight visual changes, (b) provide estimates of likely

changes in intracranial pressure and venous pressure in space, and (c) offer predictions

about future visual changes in an individual. This could provide unique insights into the

etiology of microgravity-induced vision changes, as well as serve as a diagnostic tool.

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