Task Portable Quantitative Ultrasound with DXA/QCT and FEA Integration for Human Longitudinal Critical Bone Quality Assessment (Completed)
Last Published:  03/26/21 03:34:00 PM (Central)
Short Title: Portable Quantitative Ultrasound
Responsible HRP Element: Exploration Medical Capability
Collaborating Org(s):
National Space Biomedical Research Institute (NSBRI)
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
1. To develop a new broadband SCAN system capable of extracting trabecular QUS parameters and backscatter images at critical skeletal sites using single crystal material transducer with minimal loss of the acoustic signal and integration with scan technology to provide direct assessment of the risk of osteoporotic bone loss and fracture in the deep tissue. The scanning time will be less than 2 min. The SCAN system will be non-invasive, portable, easy to use, and automatic analysis. A portable device with broadband technology will be designed and delivered upon completion of the project.
2. To evaluate the capability of the broadband SCAN diagnostic system in assessing trabecular bone structural and strength parameters in cadaver subjects with μCT determined microstructure and BMD determined by DXA. New algorism for identifying principal angle of trabecular bone noninvasively will be developed. The correlation between ultrasound assessment parameters and microstructural orientation, nanoindentor determined integrity and true modulus, and contact mechanical test determined bulk modulus will be performed in multiple skeletal sites.
3. To longitudinally assess and correlate the degree of bone loss in osteoporosis clinic, bedrest facility to determine intra-subject bone loss and the relationship to age, gender, and rational effects at critical sites using SCAN, DXA, QCT, and FEA.
4. To determine the ability of quantitative ultrasound in pre- and post-flights, as well as rehabilitation effects for astronauts.

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