Funding Status:
Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
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Aims:
SA1: To identify a set of differential vascular and then circulating oxidative protein modifications (OPTMS) in a mouse model of radiation induced vascular injury, and flown.
SA2a: To determine whether these modified peptides are associated with impaired coronary endothelial function in mice.
SA2b: To determine whether these modified peptides are associated with impaired coronary endothelial function in flown Astronauts.
SA3: To determine whether Xanthine Oxidase inhibition can alter OPTM proteomic signatures and attenuate endothelial dysfunction.