HRR - Task - Radiation Induced Cardiovascular Oxidative Stress: Thiol Modification of Proteins and Novel and Sensitive Biomarkers (Thiol Mod-Berkowitz, Completed)

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Radiation Induced Cardiovascular Oxidative Stress: Thiol Modification of Proteins and Novel and Sensitive Biomarkers (Thiol Mod-Berkowitz, Completed) (Completed)

Last Published: 04/20/22 11:43:24 AM (Central)

Task Book: Entry Unavailable
Principal Investigator: Berkowitz, Dan

Short Title: Thiol Mod

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

National Space Biomedical Research Institute (NSBRI)

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Directed

Aims:

SA1: To identify a set of differential vascular and then circulating oxidative protein modifications (OPTMS) in a mouse model of radiation induced vascular injury, and flown.

SA2a: To determine whether these modified peptides are associated with impaired coronary endothelial function in mice.

SA2b: To determine whether these modified peptides are associated with impaired coronary endothelial function in flown Astronauts.

SA3: To determine whether Xanthine Oxidase inhibition can alter OPTM proteomic signatures and attenuate endothelial dysfunction.

Resources (None Listed)

Deliverables (1)

Category: Technology or Tool
Subcategory: Systems Solutions, Prototype Hardware or Software

Description:
Study outcome will provide knowledge on whether Xanthine Oxidase inhibition can alter OPTM proteomic?signatures and attenuate endothelial dysfunction, if arginase is unregulated in radiation induced vascular injury, and whether arginase inhibition may be vascular protective.

Internal Customers:
Human Health Countermeasures
External Customers:
None

Mappings

Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Radiation Induced Cardiovascular Oxidative Stress: Thiol Modification of Proteins and Novel and Sensitive Biomarkers (Thiol Mod-Berkowitz, Completed)

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Risk Approach Plans (2)

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	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes