Task The Effects of Space Radiation on Stem Cells and Vascular and Cardiac Disease (Completed)
Last Published:  07/30/20 02:45:15 PM (Central)
Short Title: SR Stem Vascular Cardiac
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
The integrity of organs and tissues is maintained through continued cell production to replace damaged or senescent cells.  In particular stem cells are pivotal to this process providing the primary source for production of functional cells.  In the heart, cardiac stem cells (CSCs) reside in close proximity to stromal cells or mesenchymal stem cells (MSCs) that produce proteins that control the growth and development.  Stem cells are quiescent cells that cycle through self-replication very slowly.  This decreases the ability of these cells to repair damage to DNA and may lead to increased risks of vascular and heart disease.  In this application we will evaluate the effects of exposure of stem cells to spaceflight-relevant radiation.
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