Task Solid Tumor Risk Estimation: Incorporating Intercellular Interaction Effects-NNX11AK26G (Completed)
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: Tumor Risk
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
We argue that essential population-level and tumor-environmental dynamics can alter this picture dramatically, either promoting cancer development or slowing the course of existing cancers. Their basis extends beyond DNA damage to include the familiar “hallmarks” of cancer that constitute “bottlenecks” to tumor advancement – population-level logistic growth effects, acquisition of angiogenic potential, and competency for invasion, to name three. We have shown that radiation can progress or limit cancers by modifying these bottlenecks. Because these bottlenecks may be significant enough to increase the likelihood of transforming an initiated cell, or to change the likelihood an existing cancer advances to clinical detection over a lifetime, they must be included in our overall assessment of radiogenic cancer risk. It follows that existing models that fail to include such bottleneck effects are inherently flawed in that they do not include all radiation actions bearing on the development of manifest cancer disease.
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Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here!TaskSolid Tumor Risk Estimation: Incorporating Intercellular Interaction Effects-NNX11AK26G

RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
You are here!TaskSolid Tumor Risk Estimation: Incorporating Intercellular Interaction Effects-NNX11AK26G

RiskRisk of Radiation Carcinogenesis
You are here!TaskSolid Tumor Risk Estimation: Incorporating Intercellular Interaction Effects-NNX11AK26G