Task Radiation-Induced Early Changes in Gene and Protein Expression, Lipid Oxidative States, and Vascular Function Related to Atherosclerosis (Completed)
Last Published:  07/30/20 02:45:15 PM (Central)
Short Title: SR Vascular Atherosclerosis
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:

Aim 1: Determine, as a function of radiation dose, acute, radiation-induced atherosclerosis is associated changes in gene and protein expression in aortic endothelial cells of irradiated mice.

Aim 2: Determine, as a function of radiation dose, changes in oxidation states of aortic endothelial cell lipids.

Aim 3: Determine the dose dependence of functional consequences of 56Fe, and protons with respect to perturbations in endothelial reactivity and aortic adhesivity.

Aim 4: Develop a systems biology model of response of aortic endothelial cells to radiation damage to determine molecular mechanisms.

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