Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: HZE-induced Tumorigenesis
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
Here, we will test the hypothesis that microRNAs that regulate the expression of proteins that are known to regulate radiation-induced cancer, will function as non-protein encoding genetic factors that mediate radiation carcinogenesis from HZE particles. To test this hypothesis, we will utilize novel genetically engineered mice in which we can delete or overexpress miR-182. Mice will be exposed to low LET and HZE particle radiation.
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Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here!TaskDefining the role of miR-182 in HZE-Induced Tumorigenesis

RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
You are here!TaskDefining the role of miR-182 in HZE-Induced Tumorigenesis

RiskRisk of Radiation Carcinogenesis
You are here!TaskDefining the role of miR-182 in HZE-Induced Tumorigenesis