Short Title:
HZE-induced Tumorigenesis
Responsible HRP Element:
Space Radiation
Funding Status:
Completed - Task completed and produced a deliverable
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Procurement Mechanism(s):
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Aims:
Here, we will test the hypothesis that microRNAs that regulate the expression of proteins that are known to regulate radiation-induced cancer, will function as non-protein encoding genetic factors that mediate radiation carcinogenesis from HZE particles. To test this hypothesis, we will utilize novel genetically engineered mice in which we can delete or overexpress miR-182. Mice will be exposed to low LET and HZE particle radiation.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Final Report on mechanisms of the RBE/LET relationship for carcinogenesis
Internal Customers:
None
External Customers:
None