Task Contribution of GCR Exposure to Hematopoietic Stem Cell Dysfunction and Oncogenesis (Completed)
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: GCR Stem Cell Dysfunction
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
We propose to study the effects of high-LET (linear energy transfer) radiation characteristic of GCR on hematopoietic stem and progenitor cells in vivo and determine changes in HSC behavior that may predispose to leukemia and lymphoma development. Of importance is the fact that the average age of a shuttle crew has risen above 46 years, and our work and others have shown that HSCs display diminished function with age. Recent data from our group has demonstrated that middle-aged individuals show frequent defects in DNA mismatch repair in HSCs. We will therefore use a DNA repair deficient mouse models to study the effects of heavy ion radiation on HSCs that represent HSCs of potential astronaut populations, and determine whether exposure to high charge and energy (HZE) particles and the additional delta rays produced in their traversal through matter will disrupt the hematopoietic niche.
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Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here!TaskContribution of GCR Exposure to Hematopoietic Stem Cell Dysfunction and Oncogenesis

RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
You are here!TaskContribution of GCR Exposure to Hematopoietic Stem Cell Dysfunction and Oncogenesis

RiskRisk of Radiation Carcinogenesis
You are here!TaskContribution of GCR Exposure to Hematopoietic Stem Cell Dysfunction and Oncogenesis