Task Changes in the Neuroproteome Associated with HZE-Induced Impairment of Cognition
Last Published:  07/30/20 02:45:15 PM (Central)
Short Title: HZE Neuroproteome- CBS Supplement (Britten)
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Space Radiation (SR) Element
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:
Original HZE Neuroproteome Task was completed by SR in 2019, and a CBS Supplement awarded to explore the Sex Differences as an add-on to the original aims.

Aim 1. Determine the Threshold dose for the induction of HISMI and HIASSI following exposure to 56Fe, 48Ti, and 28Si particles when delivered as a single dose.

Aim 2. Determine the Threshold dose for the induction of HISMI and HIASSI following exposure to 56Fe, 48Ti, and 28Si particles when delivered in three fractions over a 5-day period.

Aim 3. Identify changes in the neuroproteome that are associated with susceptibility or resistance to developing HISMI and HIASSI following exposure to 56Fe particles.

Aim 4. Determine the mechanism of HISMI and HIASSI induced by HZE particles of differing LET.


CBS Supplement Aim 1: Establish the impact that that re-irradiation with 10 cGy of simplified (5-ion) CGRsim beam has on the ATSET performance of male Wistar rats that maintained a functional ATSET performance after exposure to 10 cGy of either He or GCRsim.
CBS Supplement Aim 2: Establish the impact that that re-irradiation with 10 cGy of simplified (5-ion) CGRsim beam has on the ATSET performance of female Wistar rats that maintained a functional ATSET performance after exposure to 10 cGy of either He or GCRsim.
Mappings
RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapBMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
GapBMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
GapBMed-107: What are the long-term changes and risks to astronaut health post-mission that, when using a continuity of care model, helps retrospectively identify and understand individual susceptibility (e.g., hereditary, dose, thresholds) to mitigate adverse CNS, cognitive, and behavioral health changes resulting from long-duration exploration missions, promoting the behavioral health of current and future crews?
GapBMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.
You are here!TaskChanges in the Neuroproteome Associated with HZE-Induced Impairment of Cognition

RiskRisk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
You are here!TaskChanges in the Neuroproteome Associated with HZE-Induced Impairment of Cognition