Task Impact of Space Radiation on Cognition, Synapses and Biomarkers in Aging and Alzheimer's Disease (Completed)
Last Published:  07/30/20 02:45:15 PM (Central)
Short Title: Cognition and Biomarkers in AD
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):

The specific aims of this study are:


Aim 1.  Determine the gender-specific early and late effects of space radiation on cognition, synaptic changes, Alzheimer’s Disease (AD) pathogenesis, cerebral blood flow (CBF) and neuroinflammation (GE180 PET) in a well-characterized Alzheimer’s Tg mouse model bearing 2 familial mutations (APPswe and PS1dE9) associated with early-onset AD and strain-, age, and gender-matched C57BL/6 WT mice. 


Aim 2.  Comparison of the effects of a single dose versus fractionated irradiation with 1000 MeV/μ 56 Fe ions on cognition and locomotion, as well as changes in cerebral blood flow, brain volume, neuroinflammation, synapses, AD pathogenesis and neuron loss.

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