Task Assess Glymphatic Changes for Spaceflight
Last Published:  07/29/22 01:33:24 PM (Central)
Short Title: Assess Glymphatic Changes for Spaceflight
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Funding Status: Planned-Funded - Task expected to be within budget
Procurement Mechanism(s):

In their evaluation of rodents, researchers from the University at Rochester have recently discovered that cerebral spinal fluid moves quickly and deeply into the brain to flush out cellular waste and minimize neuronal plaque (the hallmark of Alzheimer's). This process appears to be approximately 80% more efficient when we sleep; more recent studies have shown that postural changes (e.g. sitting to supine) contributes to this effect as well.

The purpose of this task is to conduct a study using head-down-tilt that evaluates the relationship between fluid shifts experienced in spaceflight, sleep loss, and changes in the glymphatic system. Results from the study will inform the likelihood and consequence of this risk.

This task will contribute to gap closure by informing the key threats for behavioral health and performance for a future exploration missions.

RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapBMed-101: We need to identify, quantify, and validate the key selection factors for astronaut cognitive and behavioral strengths (e.g., resiliency) and operationally-relevant performance threats for increasingly Earth independent, long-duration, autonomous, and/or long-distance exploration missions.
GapBMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
GapBMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.
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RiskRisk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
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RiskRisk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
You are here!TaskAssess Glymphatic Changes for Spaceflight