Task Assess Glymphatic Changes for Spaceflight
Last Published:  07/31/19 10:05:33 AM (Central)
Short Title: Assess Glymphatic Changes for Spaceflight
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Funding Status: Planned-Funded - Task expected to be within budget
Procurement Mechanism(s):

In their evaluation of rodents, researchers from the University at Rochester have recently discovered that cerebral spinal fluid moves quickly and deeply into the brain to flush out cellular waste and minimize neuronal plaque (the hallmark of Alzheimer's). This process appears to be approximately 80% more efficient when we sleep; more recent studies have shown that postural changes (e.g. sitting to supine) contributes to this effect as well.

The purpose of this task is to conduct a study using head-down-tilt that evaluates the relationship between fluid shifts experienced in spaceflight, sleep loss, and changes in the glymphatic system. Results from the study will inform the likelihood and consequence of this risk.

This task will contribute to gap closure by informing the key threats for behavioral health and performance for a future exploration missions.