HRR - Task - Developing Personalized Countermeasures for Sensorimotor Adaptability: A Bedrest Study (Mulavara)

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Developing Personalized Countermeasures for Sensorimotor Adaptability: A Bedrest Study (Mulavara) (Completed)

Last Published: 07/30/20 02:45:15 PM (Central)

Task Book: Entry
Principal Investigator: Mulavara, Ajitkumar

Short Title: Sensorimotor Predictors - Retrospective

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

National Space Biomedical Research Institute (NSBRI)

Other:

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Solicited

Aims:
Specific Aim 1: Determine whether baseline individual sensory biases and capabilities for strategic and plastic-adaptive responses predict both change and also the ability to re-adapt sensorimotor and functional performance after 70 days bed rest or short/long duration space flight.

Specific Aim 2: Determine if baseline brain morphological and functional metrics predict both change and also the ability to re-adapt sensorimotor and functional performance after 70 days bed rest or short/long duration space flight.

Specific Aim 3: Determine if genetic markers predict both change and also the ability to readapt sensorimotor and functional performance after 70 days bed rest or short/long duration space flight.

This task also informs BHP gaps: BMed3 and Sleep4.

Resources (Other)

Deliverables (1)

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:

This task was designed to contribute to gap closure by producing a set of predictive measures (including behavioral, brain imaging, and genomic measures) to determine individual capability for rapid sensorimotor adaptation allowing the implementation of sensorimotor adaptability training countermeasures that can be customized for each crewmember’s sensory bias and individual adaptive capability.

Due to a lack of astronaut and bed rest subject availability, only preliminary results from supplementary ground studies were delivered in the final report; however, the results are promising. A follow-on study to complete testing on astronauts will be considered.

Rachael D. Seidler, Ajitkumar P. Mulavara, Jacob J. Bloomberg and Brian T. Peters. Individual predictors of sensorimotor adaptability. Frontiers of System Neuroscience Volume 9 article 100 doi: 10.3389/fnsys.2015.00100., 05/2015.

Rahul Goel, Yiri De Dios, Nichole Gadd, Erin Caldwell, Brian Peters, Millard Reschke, Jacob Bloomberg, Lars Oddsson, and Ajitkumar Mulavara. Assessing Somatosensory Utilization during Unipedal Postural Control. Frontiers in System Neuroscience April 2017, vol 11, 21 https://doi.org/10.3389/fnsys.2017.00021., 04/2017.

Internal Customers:
Human Health Countermeasures
External Customers:
None

Mappings

Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight

SM-101: Characterize the effects of short and long-duration weightlessness, with and without deep-space radiation, on postural control and locomotion (gross motor control) after g transitions. Critical mission tasks: Ability to stand upright without falling, ability to walk safely without tripping or stumbling, ability to quickly egress from a vehicle, etc.

SM-102: Effects of short and long-duration weightlessness, with and without deep-space radiation, on manual control (fine motor control) after g transitions. Critical mission tasks: Hand-eye coordination, robotic tasks, driving (e.g., rovers), docking, landing, manipulating controls/switches/touch-screens, etc.

SM-103: Effects of short and long-duration weightlessness, with and without deep-space radiation, on spatial orientation and motion sickness after G transitions. Performance impacts that effect critical mission tasks: G-transition motion sickness, diplopia, hand-eye coordination, autonomic dysfunction, vertigo.

SM-104: How do weightlessness-induced changes in sensorimotor/vestibular function relate to and/or interact with changes in other brain functions (sleep, cognition, attention).

Developing Personalized Countermeasures for Sensorimotor Adaptability: A Bedrest Study (Mulavara)

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PRRs (2)

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Common Item(s)
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
	SM-101: Characterize the effects of short and long-duration weightlessness, with and without deep-space radiation, on postural control and locomotion (gross motor control) after g transitions. Critical mission tasks: Ability to stand upright without falling, ability to walk safely without tripping or stumbling, ability to quickly egress from a vehicle, etc.
	SM-103: Effects of short and long-duration weightlessness, with and without deep-space radiation, on spatial orientation and motion sickness after G transitions. Performance impacts that effect critical mission tasks: G-transition motion sickness, diplopia, hand-eye coordination, autonomic dysfunction, vertigo.