Task Vertebral strength and fracture risk following long duration spaceflight (Completed)
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: Vertebral Strength Analysis
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):

Retrospective Flight Study

This research will help us to better understand risk factors for vertebral fracture. Vertebral fractures are the most common fracture among older adults on Earth, with a prevalence of 30-50% among those over age 50. Improved insight into the factors that increase risk for vertebral fracture could advance the clinical management of older adults and inform better approaches to prevent these fractures.
1. Determine changes in lumbar vertebral strength in long-duration ISS astronauts using existing crewmember micro CT imaging data.
2. Compute subject specific load-to-strength ratio to estimate vertebral fracture risk in long-duration ISS astronauts
3. Simulate dynamic ‘strength’ condi6ons by altering the mechanical proper6es of the bone and disc to reflect high-rate loading