HRR - Task - Skeletal Responses to Long-Duration Simulated Microgravity in Male and Female Rats (Globus)

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Skeletal Responses to Long-Duration Simulated Microgravity in Male and Female Rats (Globus) (Completed)

Last Published: 07/29/22 01:33:24 PM (Central)

Task Book: Entry
Principal Investigator: Globus, Ruth

Short Title: Skeletal Response-Rodent

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Solicited

Aims:

Aim 1: Determine structural and gene expression changes in cortical and cancellous bone in

growing rats (3 month old) during long-duration simulated microgravity exposure and recovery.

Aim 2: Determine whether skeletal responses to long-duration simulated microgravity differ

in males compared to females (3 month old).

Aim 3: Determine age effects (9 mo old) on temporal changes in skeletal structure and gene

expression during extended simulated microgravity followed by recovery.

Resources (Other)

Deliverables (1)

Category: Study Results
Subcategory: Customer Requested Study or Analysis

Description:
Knowledge by examining how simulated weightlessness, by hind limb unloading (HLU), and recovery during reambulation regulate oxidative stress-related gene expression over time; we predict that osteoclastogenic and oxidative stress-related factors relates directly to the extent of bone decrements.

Internal Customers:
None External Customers:
None

Mappings

Risk of Bone Fracture due to Spaceflight-induced Changes to Bone

Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Skeletal Responses to Long-Duration Simulated Microgravity in Male and Female Rats (Globus)

Risk Of Early Onset Osteoporosis Due To Spaceflight

Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Skeletal Responses to Long-Duration Simulated Microgravity in Male and Female Rats (Globus)

Related Tasks (74)

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Risk Approach Plans (1)

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Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.