Short Title:
Spinal Structure-Rodent
Responsible HRP Element:
Human Health Countermeasures
Funding Status:
Completed - Task completed and produced a deliverable
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Procurement Mechanism(s):
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Aims:
Test the hypotheses that (1) simulated microgravity by hind limb unloading (HLU) leads to supraphysiologic disc swelling and increased disc height that may stiffen the lumbar motion segment and cause abnormal segmental movement patterns, (2) deconditioning of paraspinal muscles contributes to decrements in vertebral and intervertebral disc variables, and (3) different mechanisms regulate the observed skull-calvaria bone growth during actual spaceflight as compared to simulated microgravity.
Other Resources
| Other Resources Needed?
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Yes
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Category:
Study Results
Subcategory:
Customer Requested Study or Analysis
Description:
Data from actual spaceflight will provide quantitative results by which hind-limb suspension can be validated as a suitable simulated-microgravity model for the spine. This will allow US and international space investigators to understand possible differences between the hind-limb suspension model and actual microgravity.
Internal Customers:
None
External Customers:
None