Task Sclerostin's role in regulating bone formation during long-term simulated microgravity and subsequent recovery (Bloomfield) (Completed)
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: Sclerostin-Rodent
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):

Determine by immunohistochemistry (IHC) the evolution of changes in sclerostin expression (Scl-IHC) in osteocytes and osteoblast-driven bone formation in 3 separate long bone compartments of adult rats during 90 days of hindlimb suspension (HLS) and subsequent 90 days weightbearing recovery.  In calvarial bone determine if 90-day HLS alters sclerostin IHC expression in osteocytes and bone formation activity, and the time course of recover therefrom.  Determine if these responses vary by sex over 90 days of recovery by determining the same outcomes in age-matched females.