Funding Status:
Terminated - A formerly active task that was stopped before its completion date due to deselection, descoping, reorganization etc.
Procurement Mechanism(s):
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Aims:
Aim #1. Determine the effect of the hypoxic
condition associated with the exploration atmosphere on leukocyte distribution
and immunocyte function during orbital spaceflight. Both pre-flight and on-orbit normoxic data
will serve as control for the post-exploration atmosphere exposure
assessment. Aspects of both
innate and adaptive immunobiology including leukocyte distribution and various
aspects of cellular function and cytokine production profiles will be assessed.
Aim #2. Correlate the levels and effect of OSaD caused
by the 8/34 proposed exploration atmosphere with immune and inflammatory
biomarkers and cellular DNA damage
during orbital flight.
Aim #3. Correlate the
levels and effect of OSaD caused by
intermittent hypoxic and hyperoxic conditions associated with the
proposed exploration atmospheres for extended space flight missions with immune
and inflammatory biomarkers and cellular DNA