Task Deep Space Exploration Atmosphere Effects on Hematologic, Immunologic, and Oxidative Stress and Damage Parameters in Astronauts: An ISS Flight Study
Last Published:  07/31/19 10:05:33 AM (Central)
Short Title: HIOS Study
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Other:
Funding Status: Terminated - A formerly active task that was stopped before its completion date due to deselection, descoping, reorganization etc.
Procurement Mechanism(s):
Solicited
Aims:

Aim #1.   Determine the effect of the hypoxic condition associated with the exploration atmosphere on leukocyte distribution and immunocyte function during orbital spaceflight.   Both pre-flight and on-orbit normoxic data will serve as control for the post-exploration atmosphere exposure assessment.  Aspects of both innate and adaptive immunobiology including leukocyte distribution and various aspects of cellular function and cytokine production profiles will be assessed.



Aim #2.  Correlate the levels and effect of OSaD caused by the 8/34 proposed exploration atmosphere with immune and inflammatory biomarkers and cellular DNA damage  during orbital flight.

 

Aim #3.  Correlate the levels and effect of OSaD caused by   intermittent hypoxic and hyperoxic conditions associated with the proposed exploration atmospheres for extended space flight missions with immune and inflammatory biomarkers and cellular DNA

 

 

 

Mappings
RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
You are here!TaskDeep Space Exploration Atmosphere Effects on Hematologic, Immunologic, and Oxidative Stress and Damage Parameters in Astronauts: An ISS Flight Study

RiskRisk of Adverse Health Event Due to Altered Immune Response
You are here!TaskDeep Space Exploration Atmosphere Effects on Hematologic, Immunologic, and Oxidative Stress and Damage Parameters in Astronauts: An ISS Flight Study

RiskRisk of Inadequate Nutrition
You are here!TaskDeep Space Exploration Atmosphere Effects on Hematologic, Immunologic, and Oxidative Stress and Damage Parameters in Astronauts: An ISS Flight Study

RiskRisk of Injury and Compromised Performance Due to EVA Operations
You are here!TaskDeep Space Exploration Atmosphere Effects on Hematologic, Immunologic, and Oxidative Stress and Damage Parameters in Astronauts: An ISS Flight Study