HRR - Task - Deep Space Exploration Atmosphere Effects on Hematologic, Immunologic, and Oxidative Stress and Damage Parameters in Astronauts: An ISS Flight Study

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Deep Space Exploration Atmosphere Effects on Hematologic, Immunologic, and Oxidative Stress and Damage Parameters in Astronauts: An ISS Flight Study

Last Published: 04/20/22 11:43:24 AM (Central)

Task Book: Entry
Principal Investigator: Crucian, Brian

Short Title: HIOS Study

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Funding Status: Terminated - A formerly active task that was stopped before its completion date due to deselection, descoping, reorganization etc.

Procurement Mechanism(s):

Solicited

Aims:

Aim #1. Determine the effect of the hypoxic condition associated with the exploration atmosphere on leukocyte distribution and immunocyte function during orbital spaceflight. Both pre-flight and on-orbit normoxic data will serve as control for the post-exploration atmosphere exposure assessment. Aspects of both innate and adaptive immunobiology including leukocyte distribution and various aspects of cellular function and cytokine production profiles will be assessed.

Aim #2. Correlate the levels and effect of OSaD caused by the 8/34 proposed exploration atmosphere with immune and inflammatory biomarkers and cellular DNA damage during orbital flight.

Aim #3. Correlate the levels and effect of OSaD caused by intermittent hypoxic and hyperoxic conditions associated with the proposed exploration atmospheres for extended space flight missions with immune and inflammatory biomarkers and cellular DNA

Resources (Flight)

Deliverables (1)

Category: Study Results
Subcategory: Customer Requested Study or Analysis

Description:
This study will provide a report with evidence that the proposed exploration atmosphere regimen, in conjunction with the significant on-orbit stressors associated with spaceflight, will elevate OSaD and further exacerbate both immune dysregulation and cellular DNA damage.

Internal Customers:
None External Customers:
None

Mappings

Risk of Adverse Health Event Due to Altered Immune Response

IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

IM-102: Evaluate the effects of altered atmospheric conditions such as elevated CO2 levels or mildly hypoxic exploration atmosphere on immune dysfunction.

Deep Space Exploration Atmosphere Effects on Hematologic, Immunologic, and Oxidative Stress and Damage Parameters in Astronauts: An ISS Flight Study

Risk of Injury and Compromised Performance Due to EVA Operations

EVA-201: Evaluate EVA performance, physiological/cognitive metrics, and injury risk when EVAs are conducted in a variable pressure suit.

Deep Space Exploration Atmosphere Effects on Hematologic, Immunologic, and Oxidative Stress and Damage Parameters in Astronauts: An ISS Flight Study

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Risk Approach Plans (5)

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Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.