HRR - Task - Combined Effects of Space Radiation and Microgravity on the Function of Human Capillaries and the Endothelial Barrier: Implications for Degenerative Disorders

NASA Logo Human Research Roadmap HRP Exploration Data

Evidence Risks Gaps Tasks Reports

Explore Search

- CV8
  - Arrhythmia
- CVD-103
  - CVD
- Degen - 7
  - CVD
  - Degen
- IM-401
  - Immune
- IM8
  - Immune

Combined Effects of Space Radiation and Microgravity on the Function of Human Capillaries and the Endothelial Barrier: Implications for Degenerative Disorders

Last Published: 07/30/20 02:45:15 PM (Central)

Task Book: Entry
Principal Investigator: Grabham, Peter

Short Title: Implications for Degenerative Disorders

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Funding Status: Active - Currently funded and in progress

Procurement Mechanism(s):

Solicited

Aims:

Specific aim 1 endothelial barrier function.

To determine the permeability and tight junction integrity of experimental models

exposed to high and low LET space radiation in conjunction with microgravity.

Specific aim 2 Angiogenesis and mature vessel integrity.

To determine the additive or synergistic effect of microgravity on the effect of space

radiation on angiogenesis and on mature vessels.

Resources (None Listed)

Deliverables (1)

Category: Study Results
Subcategory: Customer Requested Study or Analysis

Description:
Knowledge of the effects of space radiation in combination with microgravity on the function of the vasculature can greatly advance our understanding of the degenerative effects of the space environment under normal conditions, and under conditions of physiological stress.

Internal Customers:
None External Customers:
None

Mappings

Risk of Adverse Health Event Due to Altered Immune Response

IM-401: Test, optimize and validate nutrition-based preventive/mitigative countermeasures

Combined Effects of Space Radiation and Microgravity on the Function of Human Capillaries and the Endothelial Barrier: Implications for Degenerative Disorders

Risk of Spaceflight Induced Cardiovascular Disease

CVD-103: To determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

Combined Effects of Space Radiation and Microgravity on the Function of Human Capillaries and the Endothelial Barrier: Implications for Degenerative Disorders

Related Tasks (143)

Print View...

PRRs (4)

NASA Developer: Daniel Febus Responsible NASA Official: Susan Torney Contact HRP for a 508 compliant PDF Budgets, Strategic Plans, and Accountability Reports Equal Employment Opportunity Data Posted Pursuant to the No Fear Act Information-Dissemination Policies and Inventories Freedom of Information Act President's Management Agenda Privacy Policy & Important Notices Inspector General Hotline Contact HRP Human Health and Performance DIR Johnson Space Center USA.gov ExpectMore.gov

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-401: Test, optimize and validate nutrition-based preventive/mitigative countermeasures