HRR - Task - Combined Effects of Space Radiation and Microgravity on the Function of Human Capillaries and the Endothelial Barrier: Implications for Degenerative Disorders

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Combined Effects of Space Radiation and Microgravity on the Function of Human Capillaries and the Endothelial Barrier: Implications for Degenerative Disorders

Last Published: 07/29/22 01:33:24 PM (Central)

Task Book: Entry
Principal Investigator: Grabham, Peter

Short Title: Implications for Degenerative Disorders

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Funding Status: Active - Currently funded and in progress

Procurement Mechanism(s):

Solicited

Aims:

Specific aim 1 endothelial barrier function.

To determine the permeability and tight junction integrity of experimental models

exposed to high and low LET space radiation in conjunction with microgravity.

Specific aim 2 Angiogenesis and mature vessel integrity.

To determine the additive or synergistic effect of microgravity on the effect of space

radiation on angiogenesis and on mature vessels.

Resources (None Listed)

Deliverables (1)

Category: Study Results
Subcategory: Customer Requested Study or Analysis

Description:
Knowledge of the effects of space radiation in combination with microgravity on the function of the vasculature can greatly advance our understanding of the degenerative effects of the space environment under normal conditions, and under conditions of physiological stress.

Internal Customers:
None External Customers:
None

Mappings

Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

CV-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

Combined Effects of Space Radiation and Microgravity on the Function of Human Capillaries and the Endothelial Barrier: Implications for Degenerative Disorders

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Risk Approach Plans (2)

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Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes