Task Development of a Flow-Perfused and Immunocompetent 3-D Vascular Model for Radiation Risk Assessment of Cardiovascular Disease and Countermeasure Screening (Completed)
Last Published:  07/30/20 02:45:15 PM (Central)
Short Title: 3-D Vascular Model
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
Aim 1: Establish a 3-D tri-culture vascular model which incorporates aortic endothelial cells, smooth muscle cells, and macrophages.

Aim 2
: Adapt the 3-D model from its organotypic configuration within a hydrogel to a spheroid format for use in rotating wall vessel bioreactors.

 

Aim 3: Validate the utility of the 3-D vascular model for radiation risk assessment studies.
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