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Task Oxidative Stress and the Cancer Risk of Space Radiation
Last Published:  11/23/20 11:55:12 AM (Central)
Task Book: Entry
Principal Investigator: Azzam, Edouard
Short Title: Oxidative Stress and Cancer Risk
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:

Aim 1: To examine chronic oxidative stresses and inflammatory responses in organs of mice exposed to isovelocity 1 GeV/n O, Si, or Ca ions that are targeted to the whole body.


Aim 2: To determine the beneficial effects of a pre-exposure to low LET protons that

may minimize the harmful effects of a subsequent exposure to HZE particles.


Aim 3: To measure oxidative changes and cancer incidence in non-irradiated organs

(liver, lung) after exposure of the head to an acute mean absorbed dose of 40 cGy of 1 GeV/u Ca,and to compare the observed changes with those in a targeted organ (brain). b) To examine the protective effect of whole-body pre-exposure to a conditioning dose of 20 cGy of 1 GeV protons delivered at low dose-rate prior to head exposure to acute dose of 40 cGy of 1 GeV/u Ca ions.

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Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here!TaskOxidative Stress and the Cancer Risk of Space Radiation
RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
You are here!TaskOxidative Stress and the Cancer Risk of Space Radiation
RiskRisk of Radiation Carcinogenesis
You are here!TaskOxidative Stress and the Cancer Risk of Space Radiation