Funding Status:
Completed - Task completed and produced a deliverable
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Procurement Mechanism(s):
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Aims:
Aim 1: To examine chronic oxidative stresses and inflammatory responses in organs of mice exposed to isovelocity 1 GeV/n O, Si, or Ca ions that are targeted to the whole body.
Aim 2: To determine the beneficial effects of a pre-exposure to low LET protons that
may minimize the harmful effects of a subsequent exposure to HZE particles.
Aim 3: To measure oxidative changes and cancer incidence in non-irradiated organs
(liver, lung) after exposure of the head to an acute mean absorbed dose of 40 cGy of 1 GeV/u Ca,and to compare the observed changes with those in a targeted organ (brain). b) To examine the protective effect of whole-body pre-exposure to a conditioning dose of 20 cGy of 1 GeV protons delivered at low dose-rate prior to head exposure to acute dose of 40 cGy of 1 GeV/u Ca ions.