Task Molecular characterization of transmissible chromosome aberrations produced by ions of intermediate and high atomic number
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: Chromosome Aberrations
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:

Objective 1: Isolate progeny (clones) of irradiated single cells and analyze for the presence of transmissible chromosome aberrations


Objective 2:
Next generation sequencing approaches will be employed to characterize, at the DNA level, the nature of breakpoint junctions of the chromosome translocations and inversions identified in Objective 1.


Objective 3: Examine cytogenetic Effects of Abrogating CtIP activity.
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