Task Neurobehavioral and CNS-Related Physiological Changes Following Space Radiation (Completed)
Last Published:  07/31/19 10:05:33 AM (Central)
Short Title: Neurobehavioral & CNS
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Other:
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:

Aim 1. Assess the immediate and long-term effects of radiation on spontaneous locomotor activity and body temperature, two primary indices of circadian function, in individual animals.


Aim 2
. Assess post-irradiation mRNA and protein expression in brain regions important for sustained attention and circadian function.

Resources (None Listed)
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here!TaskNeurobehavioral and CNS-Related Physiological Changes Following Space Radiation

RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapCBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.
GapCBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
GapCBS-CNS - 3: How does individual susceptibility including hereditary pre-disposition (e.g. Alzheimer’s, Parkinson’s, apoE allele) and prior CNS injury (e.g. concussion, chronic inflammation or other) alter significant CNS risks? Does individual susceptibility modify possible threshold doses for these risks in a significant way?
You are here!TaskNeurobehavioral and CNS-Related Physiological Changes Following Space Radiation