Task Induction of Hepatocellular Carcinoma by Space Radiation: A Systems Biology Study of Causative Mechanisms
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: Hepatocellular Carcinoma
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:

Aim 1. Determine the microenvironmental changes in hepatic lipids by MALDI-IMS after HZE-irradiation


Aim 2
. Determine transcriptional changes in the hepatic microenvironment of

HZE- and gamma-irradiated samples, compared to controls.


Aim 3
. Determine comprehensive ultra high-resolution lipidomic alterations as well as high-resolution targeted proteomic microenvironment changes in hepatic tissue of HZE- and 137Cs gamma ray-irradiated animals as well as non-irradiated controls.


Aim 4.
Correlate large ‘omic datasets to construct biological pathways that elucidate molecular mechanisms of HCC carcinogenesis induced by HZE irradiation.

Resources (None Listed)
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here!TaskInduction of Hepatocellular Carcinoma by Space Radiation: A Systems Biology Study of Causative Mechanisms

RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
You are here!TaskInduction of Hepatocellular Carcinoma by Space Radiation: A Systems Biology Study of Causative Mechanisms

RiskRisk of Radiation Carcinogenesis
You are here!TaskInduction of Hepatocellular Carcinoma by Space Radiation: A Systems Biology Study of Causative Mechanisms