Task Radiation-induced apoptosis avoidance and colon tumorigenesis: Epigenetic regulation in adult stem cells (Completed)
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: Epigenetic Regulation
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:

Aim 1: Determine the impact of low dose HZE ions on perturbations in intestinal whole genome methylation and histone acetylation status.


Aim 2
: Determine if colon adult stem cells are more susceptible to epigenetic perturbations induced by low dose HZE radiation than non-stem cells in the same colon crypt.


Aim 3
: Determine the potential for dietary countermeasures that alter colonic microbiota and butyrate concentrations to mitigate the impact of low dose HZE radiation onepigenetic regulation of apoptosis in colon adult stem cells and daughter cells.

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