Funding Status:
Active - Currently funded and in progress
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Procurement Mechanism(s):
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Aims:
Aim 1: Quantitatively assess GI tumorigenesis in mouse models of GI cancer and collect samples for qualitative analysis.
Aim 2: Dissection of the signaling events and consequences in GI cells of the persistent effects of space radiation (e.g. oxidative stress, aberrant pro-proliferative signaling, and ongoing mitochondrial damage and dysfunction)
Aim 3: Characterization of IR-induced neoplastic events in normal diploid human colonocytes. In order to bridge in vivo mouse model tumorigenesis studies, human colonocytes will be employed to characterize space radiation induced changes and to compare to colonocytes from irradiated mice (Aims 1 and 2).
Aim 4: Development of systems biology (Project 4A) and mathematical modeling (Project 4B) approaches for GI cancer risk assessment. Genome-wide NGS combined with other omics approaches will contribute to a systems biology understanding of the effects of space radiation in the intestines and stomach.