Last Published:  07/31/19 10:05:33 AM (Central)
Short Title: Cancer Biomarkers
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Other:
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:

Project 1 - identify biomarkers for susceptibility to HZE ion carcinogenesis and for early disease detection using genetic and systems biology approaches. Uses integrative “omics” approaches over multiple levels of biological organization and involves multiple species.

 

Project 2 - focuses on the mechanisms underlying the increased malignancy of HZE ion-induced tumors compared with their spontaneous or γ- ray-induced counterparts.

 

Project 3 - examines the critical question of risk from protracted exposures to high LET radiation at low doses and dose rates. Uses chronic exposures to high LET associated neutron radiation as a surrogate for conditions of space-relevant fluence rates and total doses to estimate the carcinogenic effects.

 

Project 4 - utilizes the resources (irradiated mice and “omics” results) generated in the first three projects to study the neurobehavioral consequences of HZE ion and neutron exposures and whether they are related to cancer outcome measures and predicted by the same or distinct biomarkers
Resources (None Listed)
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
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RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
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RiskRisk of Radiation Carcinogenesis
GapCancer 01: How can experimental models of tumor development for the major tissues (lung, colon, stomach, breast, liver, and leukemias) be developed to represent the major processes in radiation carcinogenesis and extrapolated to human risk and clinical outcome projections?
GapCancer 03: How can experimental models of carcinogenesis be applied to reduce the uncertainties in radiation quality effects from SPE’s and GCR, including effects on tumor spectrum, burden, latency and progression (e.g., tumor aggression and metastatic potential)?
GapCancer 04: How can models of cancer risk be applied to reduce the uncertainties in dose-rate dependence of risks from SPE's and GCR?
GapCancer 05: How can models of cancer risk be applied to reduce the uncertainties in individual radiation sensitivity including genetic and epigenetic factors from SPE and GCR?
GapCancer 06: How can models of cancer risk be applied to reduce the uncertainties in the age and sex dependence of cancer risks from SPE's and GCR?
GapCancer 07: How can systems biology approaches be used to integrate research on the molecular, cellular, and tissue mechanisms of radiation damage to improve the prediction of the risk of cancer and to evaluate the effectiveness of countermeasures? How can epidemiology data and scaling factors support this approach?
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