Last Published:  07/30/20 02:45:15 PM (Central)
Short Title: 2026 CVD/Late CNS biomarker & CM Val
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Planned-Funded - Task expected to be within budget
Procurement Mechanism(s):
Solicited
Aims:
  • Aim 1 (CVD):  Validate efficacy of standard of care clinical protective measures in a combined stressor model with chronic mixed field exposures, evaluating for mitigation of radiation-induced CVD.

  • Aim 2 (CVD/CNS): Validate efficacy of cross-risk candidate radioprotective agents in a combined stressor model with chronic mixed field exposures, evaluating for mitigation of radiation-induced CVD and late CNS adverse outcomes.

  • Aim 3 (CVD, CNS):  Evaluate any potential antagonistic, synergistic, or additive effects across CVD protective measures and late CNS adverse outcomes.


Resources (None Listed)
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here!Task2026 NSCOR: CVD/Late CNS MCM Assessment: Combined Spaceflight Stressors

RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapBMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
GapBMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
GapBMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?
GapBMed-105: Given the potentially negative spaceflight associated CNS/cognitive changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated medical or dietary countermeasures to mitigate stressors impacting on CNS / cognition / behavioral health?
GapBMed-107: What are the long-term changes and risks to astronaut health post-mission that, when using a continuity of care model, helps retrospectively identify and understand individual susceptibility (e.g., hereditary, dose, thresholds) to mitigate adverse CNS, cognitive, and behavioral health changes resulting from long-duration exploration missions, promoting the behavioral health of current and future crews?
GapBMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.
You are here!Task2026 NSCOR: CVD/Late CNS MCM Assessment: Combined Spaceflight Stressors

RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
You are here!Task2026 NSCOR: CVD/Late CNS MCM Assessment: Combined Spaceflight Stressors

RiskRisk of Radiation Carcinogenesis
You are here!Task2026 NSCOR: CVD/Late CNS MCM Assessment: Combined Spaceflight Stressors

RiskRisk of Spaceflight Induced Cardiovascular Disease
You are here!Task2026 NSCOR: CVD/Late CNS MCM Assessment: Combined Spaceflight Stressors