Task Integrated Cardiovascular (ICV) 2.0: Assessing the Risk for Atrial Fibrillation in Astronauts During Long Duration Spaceflight [INTEGRATED CARDIOVASCULAR 2/LEVINE/ACTIVE] (Completed)
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: Integrated Cardiovascular 2
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:

The global objective of this study is to use previously collected ICV data to assess the risk for atrial fibrillation in astronauts undergoing long duration spaceflight on the ISS.

Specific Aim 1 of this application is to test the hypothesis that 6 months of spaceflight cause left

atrial dilation, and impairment of atrial function with augmented atrial filling fraction. This aim

will be accomplished by analysis of already acquired ICV MRI and echo data;

Moreover, because we have already acquired high resolution ECGs during Holter monitoring,

we can re-analyze these to evaluated changes in atrial electrophysiology (P wave signal

averaging, including amplitude, duration, and late potentials) to determine whether spaceflight

and the accompanying training increases the risk for atrial fibrillation.

Specific Aim 2 of this application is to test the hypothesis that 6 months of spaceflight alters

atrial electrical function, thereby increasing the risk of afib. This aim will be accomplished by

re-analysis of already acquired ICV Holter data.


This task also informs ExMc 1.01, 2.01, 3.01, and 4.24, as well as CV3, 7, and 8.

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