HRR - Task - Integrated Cardiovascular (ICV) 2.0: Assessing the Risk for Atrial Fibrillation in Astronauts During Long Duration Spaceflight [INTEGRATED CARDIOVASCULAR 2/LEVINE/ACTIVE]

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Integrated Cardiovascular (ICV) 2.0: Assessing the Risk for Atrial Fibrillation in Astronauts During Long Duration Spaceflight [INTEGRATED CARDIOVASCULAR 2/LEVINE/ACTIVE] (Completed)

Last Published: 11/23/20 11:55:12 AM (Central)

Task Book: Entry Unavailable
Principal Investigator: Levine, Benjamin

Short Title: Integrated Cardiovascular 2

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Solicited

Aims:

The global objective of this study is to use previously collected ICV data to assess the risk for atrial fibrillation in astronauts undergoing long duration spaceflight on the ISS.

Specific Aim 1 of this application is to test the hypothesis that 6 months of spaceflight cause left

atrial dilation, and impairment of atrial function with augmented atrial filling fraction. This aim

will be accomplished by analysis of already acquired ICV MRI and echo data;

Moreover, because we have already acquired high resolution ECGs during Holter monitoring,

we can re-analyze these to evaluated changes in atrial electrophysiology (P wave signal

averaging, including amplitude, duration, and late potentials) to determine whether spaceflight

and the accompanying training increases the risk for atrial fibrillation.

Specific Aim 2 of this application is to test the hypothesis that 6 months of spaceflight alters

atrial electrical function, thereby increasing the risk of afib. This aim will be accomplished by

re-analysis of already acquired ICV Holter data.

This task also informs ExMc 1.01, 2.01, 3.01, and 4.24, as well as CV3, 7, and 8.

Resources (Flight)

Deliverables (1)

Category: Study Results
Subcategory:

Description:

There will be 2 key deliverables for this project: analysis of data already acquired

by the ICV investigators to determine if 6 months of spaceflight alter: 1) atrial structure and

function or 2) atrial electrophysiological properties so as to increase the risk of atrial fibrillation.

Internal Customers:
None External Customers:
None

Mappings

Risk of Spaceflight Induced Cardiovascular Disease

CVD-101: Determine whether long-duration weightlessness induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Integrated Cardiovascular (ICV) 2.0: Assessing the Risk for Atrial Fibrillation in Astronauts During Long Duration Spaceflight [INTEGRATED CARDIOVASCULAR 2/LEVINE/ACTIVE]

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Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-101: Determine whether long-duration weightlessness induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.