Funding Status:
Active - Currently funded and in progress
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Procurement Mechanism(s):
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Aims:
Specific Aim 1 (Hypothesis #1 and
#2)
- To develop and validate a
noninvasive ICP estimation (nICP) approach for a specific
population of crewmembers based on
a noninvasive ICP framework (NICF). The anticipated
input parameters may include:
arterial blood pressure (ABP), electrocardiogram signals, cerebral
blood flow velocity (CBFV), heart
and ventilation rate, tympanic membrane displacement by
Cochlear and Cerebrospinal Fluid
Pressure (CCFP), ophthalmic artery blood pressure by
Vittamed. The NICF has been only
tested using ABP and CBFV data from brain injury patients.
The additional noninvasive data
elements provide different aspects of cerebral physiology under
influence of ICP. Therefore,
integrating them under the NICF is very likely to improve nICP
accuracy.
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Specific Aim 2 (Hypothesis #2)
- To longitudinally estimate ICP in
crew members before, during and after spaceflight using the
model developed in Aim 1.
Specific Aim 3 (Hypothesis #3)
- To use novel methods of mRNA and
microRNA profiling to identify candidate urinary and
plasma biomarkers that align with
VIIP-related physiologic variables.
Specific Aim 4 (Hypothesis #4)
-To measure and correlate novel
biomarkers in urine and blood of crew members with measures
of estimated ICP, pre-, in- and
post-flight.
-To use all noninvasive measures
plus biomarkers as input to build a predictive model that will
inform the likelihood of a given crew member
developing VIIP post flight.
This study will be performed in conjunction with Williams' "Zero G and ICP." It also informs gaps VIIP3, VIIP13, and CV7.