Task Mechanistic Analysis of Particle Radiation-Induced Carcinogenesis Using Validated Mouse Glioma Models
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: Mouse Glioma Models
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:

Aim 1: To assess radiation quality effects on charged particle-induced carcinogenesis using validated

glioblastoma models.

 

Aim 2: To delineate the role of NHEJ vs HR DNA repair pathways as barriers to charged particle-induced gliomagenesis.

 

Aim 3: To identify genetic signatures unique to charged particle-induced glioblastomas.

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