Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: Mouse Models Cancer Risk & Prevention
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:

Aim 1: Investigate the cellular and molecular mechanisms that contribute to the space radiation associated carcinogenic risks of mouse models of human colon and lung cancer.

 

Aim 2: Determine the probabilities for increased colonic and lung carcinogenesis from space radiation as a result of radiation dose, quality, and dose rate and to compare the biomarkers obtained from these cancer susceptible mice with those in wild type mice so we can extrapolate to risks in healthy astronauts.

 

Aim 3:  Provide statistically significant biomarker signatures and biological markers

for modeling and risk assessment for increases in cancer for astronauts during long-term space

missions.

 

Aim 4: Determine the anti-cancer effectiveness and long-term side effects, if any, of the CDDO

countermeasure to guide the most effective approaches for their use on long-term space missions.

Resources (None Listed)
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here!TaskMouse Models of Cancer Risk and Prevention from Space Radiation

RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
You are here!TaskMouse Models of Cancer Risk and Prevention from Space Radiation

RiskRisk of Radiation Carcinogenesis
You are here!TaskMouse Models of Cancer Risk and Prevention from Space Radiation