Funding Status:
Active - Currently funded and in progress
Procurement Mechanism(s):
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Aims:
Aim 1: Identify changes in brain structure, function, and network integrity as a function of 30 days head down tilt bed rest plus 0.5% CO2 and characterize their time course.
Aim 2: Specify relationships between structural and functional brain changes and performance and characterize their time course.
Aim 3: Identify predictors of individual differences in bed rest plus 0.5% CO2 responses.
The following supplemental aims were added:
1S. Characterize the dose-response effect of elevated CO2 on gadolinium contrast clearance in the human brain glymphatic system over a period of approximately 24 hours.
2S. Assess changes in brain-derived stress biomarkers in the blood that correlate with neurological changes in response to elevated CO2.
3S. Evaluate neurobehavioral responses in response to elevated CO2.