Task Mars 600/900 Simulation I: Large Animal Chronic Studies
Last Published:  07/31/19 10:05:33 AM (Central)
Short Title: Mars 600/900 Sim I
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Other:
Funding Status: Planned-Funded - Task expected to be within budget
Procurement Mechanism(s):
Solicited
Aims:

Evaluation of dose rate effects and tissue specific RBE’s for major at risk tissues using chronic mixed-field radiation with the following aims:


Specific aims

  • Aim 1 (Cancer): Research to improve accuracy of dose and dose-rate effectiveness factor (DDREF) estimates for tumorigenesis and evidence on whether risk is linear or additive over mixed high and low LET radiation exposure

  • Aim 2 (Cancer): Determine tissue specific mixed field RBE values for tumorigenesis for major at risk tissues

  • Aim 3 (CVD): Examine dose thresholds, dose-rate dependence and mixed field effects on CVD disease latency and progression; evaluate RBEs

  • Aim 4 (late CNS): Examine dose thresholds, dose-rate dependence and mixed field effects for late behavioral and neurodegenerative CNS diseases; evaluate RBEs

  • Aim 5 (CVD): Evaluate effects of chronic space radiation exposures on ‘standard of care’ clinical markers for CVD effects.

Secondary aims:

  • Aim 6: Assess the impact of simulated low dose GCR exposures on the health of the blood forming organs.

 

Studies will generate mixed field dose response curves to evaluate thresholds and RBE’s.

Resources (None Listed)
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
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RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
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RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
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RiskRisk of Radiation Carcinogenesis
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