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Task Radiation Exposures in Space and the Potential of Central Nervous System Effects Phase II (Completed)
Last Published:  07/31/19 10:05:33 AM (Central)
Task Book: Entry Unavailable
Principal Investigator: Boice, John
Short Title: SR-CNS II
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Other:
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Directed
Aims:
The NCRP will form a new scientific committee of subject matter experts in this Phase II follow-on study to address Central Nervous System Risks following space radiation exposure based on the guidelines and recommendations laid forth in the Phase 1 NCRP Commentary No. 25.  The committee's findings will be summarized in a detailed report that outlines the steps and approaches needed to more fully understand the risk of CNS effects following radiation exposures in space and to provide guidance for risk management and radiation protection.   The Committee will strive to identify any knowledge gaps regarding the implementation of a comprehensive and effective radiation safety program to protect astronauts against the potential for early and late CNS effects from space radiation. The Phase 2 committee will summarize and critically review the existing literature on each of the 5 main topics which include: 1)Mechanisms for radiation damage in the central nervous system; 2)Experimental animal research; 3) Human data; 4)Integration of data across all biological scale and 5)Interactions of radiation with other factors.
Resources (None Listed)
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
GapCBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
GapCBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
GapCBS-CNS - 3: How does individual susceptibility including hereditary pre-disposition (e.g. Alzheimer’s, Parkinson’s, apoE allele) and prior CNS injury (e.g. concussion, chronic inflammation or other) alter significant CNS risks? Does individual susceptibility modify possible threshold doses for these risks in a significant way?
GapCBS-CNS - 8: Are there significant CNS risks from combined space radiation and other physiological or space flight factors, e.g., psychological (isolation and confinement), altered gravity (micro-gravity), stress, sleep deficiency, altered circadian rhythms, hypercapnea, altered immune, endocrine and metabolic function, or other?
You are here!TaskRadiation Exposures in Space and the Potential of Central Nervous System Effects Phase II
RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapCBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.
GapCBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
GapCBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
GapCBS-CNS - 3: How does individual susceptibility including hereditary pre-disposition (e.g. Alzheimer’s, Parkinson’s, apoE allele) and prior CNS injury (e.g. concussion, chronic inflammation or other) alter significant CNS risks? Does individual susceptibility modify possible threshold doses for these risks in a significant way?
GapCBS-CNS - 8: Are there significant CNS risks from combined space radiation and other physiological or space flight factors, e.g., psychological (isolation and confinement), altered gravity (micro-gravity), stress, sleep deficiency, altered circadian rhythms, hypercapnea, altered immune, endocrine and metabolic function, or other?
You are here!TaskRadiation Exposures in Space and the Potential of Central Nervous System Effects Phase II