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Task Radiation Exposures in Space and the Potential of Central Nervous System Effects Phase II (Completed)
Last Published:  03/26/21 03:34:00 PM (Central)
Task Book: Entry Unavailable
Principal Investigator: Boice, John
Short Title: SR-CNS II
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Directed
Aims:
The NCRP will form a new scientific committee of subject matter experts in this Phase II follow-on study to address Central Nervous System Risks following space radiation exposure based on the guidelines and recommendations laid forth in the Phase 1 NCRP Commentary No. 25.  The committee's findings will be summarized in a detailed report that outlines the steps and approaches needed to more fully understand the risk of CNS effects following radiation exposures in space and to provide guidance for risk management and radiation protection.   The Committee will strive to identify any knowledge gaps regarding the implementation of a comprehensive and effective radiation safety program to protect astronauts against the potential for early and late CNS effects from space radiation. The Phase 2 committee will summarize and critically review the existing literature on each of the 5 main topics which include: 1)Mechanisms for radiation damage in the central nervous system; 2)Experimental animal research; 3) Human data; 4)Integration of data across all biological scale and 5)Interactions of radiation with other factors.
Resources (None Listed)
Mappings
RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapBMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
GapBMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
GapBMed-107: What are the long-term changes and risks to astronaut health post-mission that, when using a continuity of care model, helps retrospectively identify and understand individual susceptibility (e.g., hereditary, dose, thresholds) to mitigate adverse CNS, cognitive, and behavioral health changes resulting from long-duration exploration missions, promoting the behavioral health of current and future crews?
GapBMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.
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