HRR - Task - Effects of space flights on the proteome of astronauts' plasma (Rithidech) functional immune

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Effects of space flights on the proteome of astronauts' plasma (Rithidech) functional immune

Last Published: 11/23/20 11:55:12 AM (Central)

Task Book: Entry
Principal Investigator: Rithidech, Kanokporn

Short Title: Plasma Proteome

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Funding Status: Active - Currently funded and in progress

Procurement Mechanism(s):

Solicited

Aims:

[A] Determine the in-flight status of immune dysregulation (innate + adaptive) in conjunction with relevant parameters from other disciplines (nutrition, radiation, virology, host-pathogen, stress, etc.).

[B] Determine the post-flight time course to full recover for dysregulated parameters.

[C] Derive a final refined monitoring strategy encompassing innate immunity, adaptive immunity and relevant parameters from other disciplines which will be appropriate to validate countermeasures.

Integration/Unique Aspects: Functional immune is a hybrid study that will incorporate a directed portion with solicited portions.

Resources (Flight)

Deliverables (1)

Category:
Subcategory:

Description:
Functional immune a large integrated multi-laboratory internal/external study during the lifespan of ISS. including work data from the Integrated Immune, and the Salivary Markers studies. This study should essentially close Gap IM-01 (post completion status ~95%). The deliverable will be a report that will feed into the HHC Integrated Countermeasure Suite. The Integrated immune study confirmed certain aspects of adaptive immunity but left many others relatively investigated.

Internal Customers:
Human Health Countermeasures
External Customers:
None

Mappings

Risk of Adverse Health Event Due to Altered Immune Response

IM-105: Identify immune biomarkers that correlate with known spaceflight-related immune dysfunction and immune outcomes, as a first step in designing in-flight monitoring paradigms.

Effects of space flights on the proteome of astronauts' plasma (Rithidech) functional immune

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PRRs (1)

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Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response