Task Functional Immune -DNA damage in the ISS astronaut's lymphocytes and their association with stress-induced immune dysfunction (Honglu Wu) Functional immune
Last Published:  03/26/21 03:34:00 PM (Central)
Short Title: Functional Immune - DNA damage
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:

[A] Determine the in-flight status of immune dysregulation (innate + adaptive) in conjunction with relevant parameters from other disciplines (nutrition, radiation, virology, host-pathogen, stress, etc.).

[B] Determine the post-flight time course to full recover for dysregulated parameters.

[C] Derive a final refined monitoring strategy encompassing innate immunity, adaptive immunity and relevant parameters from other disciplines which will be appropriate to validate countermeasures.


Integration/Unique Aspects: TBD,  functional immune is a hybrid study that incorporates a directed portion with solicited portions.


Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here!TaskFunctional Immune -DNA damage in the ISS astronaut's lymphocytes and their association with stress-induced immune dysfunction (Honglu Wu) Functional immune

RiskRisk of Adverse Health Event Due to Altered Immune Response
You are here!TaskFunctional Immune -DNA damage in the ISS astronaut's lymphocytes and their association with stress-induced immune dysfunction (Honglu Wu) Functional immune

RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
You are here!TaskFunctional Immune -DNA damage in the ISS astronaut's lymphocytes and their association with stress-induced immune dysfunction (Honglu Wu) Functional immune

RiskRisk of Radiation Carcinogenesis
You are here!TaskFunctional Immune -DNA damage in the ISS astronaut's lymphocytes and their association with stress-induced immune dysfunction (Honglu Wu) Functional immune