Task Identification of Functional Metabolomic Profiles Contributing to Physiological Adaptations to Simulated Spaceflight. (Rana)
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: Metabolomic Profiles
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:

Use a hypothesis driven targeted metabolomics approach to identify

mitochondrial related metabolites in urine and serum that are associated with bed rest-induced

physiological manifestations and protected against by countermeasures (testosterone and

exercise).

Use an untargeted metabolomics approach  to identify novel metabolites and

pathways in serum associated with physiological changes induced by bed rest and protected

against by countermeasures.


Test whether serum metabolites identified in Aims 1 & 2 have the potential to

regulate mitochondrial driven cellular metabolism and if specific changes in metabolism may be

a means of detecting the risk for or monitoring the progression of physiological outcomes

induced by bed rest.


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