HRR - Task - Candidate nutritional countermeasure to mitigate adverse effects of spaceflight (Schreurs)

Efficacy of Vitamin D Supplementation in an Antarctic Ground Analog of Space Flight

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Vitamin D Supplementation in an Antarctic Ground Analog of Space Flight: Study of Supplementation Protocol and Relationship to Immune System Function

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Vitamin D Supplement Evaluation of Dosing Requirements

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Nutritional Status Assessment: SMO-016E

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N7.1: We need to identify the most important nutritional factors for musculoskeletal health.
	Osteo 7: We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight.

Dietary Intake Can Predict and Protect Against Changes in Bone Metabolism During Space Flight and Recovery (Pro-K)

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N7.1: We need to identify the most important nutritional factors for musculoskeletal health.

Characterization of Oxidative Damage During a Saturation Dive

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Vertebral Compression Fracture Assessment

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Feasibility Study: QCT Modality for Risk Surveillance of Bone - Effects of In-flight Countermeasures on Sub-regions of the Hip Bone

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Recovery of Musculoskeletal Quantity and Quality upon Multiple Microgravity Exposure

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Epidemiologic Analyses of Risk Factors for Bone Loss and Recovery Related to Long Duration Space Flight

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Contributors to Long-Term Recovery of Bone Strength following Exposure to Microgravity

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Rapid measurements of bone loss using tracer-less calcium isotope analysis of blood and urine

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Bisphosphonates as a Countermeasure to Space Flight Induced Bone Loss: SMO-021

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 7: We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight.

Cardiac Atrophy and Diastolic Dysfunction During and After Long Duration Spaceflight: Functional Consequences for Orthostatic Intolerance, Exercise Capacity, and Risk of Cardiac Arrhythmias (ICV-Bungo/Levine, Active)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Animal radiation study (Radiation Pilot-Westby, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Bracelet Investigation (Brazlet Dulchavsky, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Validation of On-Orbit Methodology for the Assessment of Cardiac Function and Changes in the Circulating Volume Using Ultrasound and Braslet-M Occlusion Cuffs, SDTO 17011 U/R (Braslet-M -- Duncan, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

The Multisystem Effect of Exercise Training/Nutritional Support During Prolonged Bed Rest Deconditioning: An Integrative Approach to Countermeasure Development for the Heart, Lungs, Muscles and Bones (Integrative CM-Levine, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Development of Spaceflight Foods with High Microbial Concentrations

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Identification of cardiometabolic vulnerabilities caused by effects of synergistic stressors that are commonly encountered during space missions (Cardiometabolic Vulnerabilities-Shea, Active)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Data Mining for Incidence of Renal Stone Formation Following Spaceflight

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Renal Stone Risk during Spaceflight: Assessment and Countermeasure Validation (Renal Stone - DSO 633)

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Effects of emotional stress on the cardiovascular system (Stress and CV Health-TBD, Planned)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Determining the Effect of Space Flight on the Incidence of Cardiovascular Risk Factors and Disease (CV Data Mining-Barstow, Active)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

Suited Contingency Ops Food

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Effects of Processing and Subsequent Storage on Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Vitamins B1 and C Degradation in Spaceflight Foods: Establishment of Prediction Models and Prevention Strategies

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Integration of Product, Package, Process, and Environment: A Food System Optimization

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Effects of Retronasal Smelling, Variety, and Choice on Appetite and Satiety

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Comparative Packaging Study

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Bulk Overwrap Packaging

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Flexible High-Barrier Polymers for Food Packaging

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Packaged Food Mass Reduction Technology Development

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Food Processing vs. Packaged Food System Trade Study

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Stability of Pharmacotherapeutics and Nutrition Compounds - Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Thermostabilized Food Study

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Effect of Space Radiation on the Nutrition and Quality of the Food

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Development of a Multipurpose Extruder/Press Food Processing System

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

ElastiGlass Barrier Film and Food Processing Techniques for the 3 to 5 Year Shelf-Stable Food Package

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Packaged Food Mass Reduction Trade Study

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Total System Approach

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Reheating and Sterilization Technology for Food, Waste and Water

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

A Multipurpose Fruit and Vegetable Processing System for Advanced Life Support

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Temperature Regulatory and Cardiovascular Responses to Exercise During Long-Duration Spaceflight

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Integrated Resistance and Aerobic Training Study (Ploutz-Snyder)

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 7: We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight.

Monitoring Bone Health by Daily Load Stimulus Measurement during Lunar Missions

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 7: We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight.

An Integrated Musculoskeletal Countermeasure Battery for Long-Duration Lunar Missions

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Integrated Nutrition: Development and Provision of Functional Foods to Mitigate Bone Loss on ISS Missions

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N7.1: We need to identify the most important nutritional factors for musculoskeletal health.

Monitoring of Bone Loss Biomarkers in Human Sweat: A Non-Invasive, Time Efficient Means of Monitoring Bone Resorption Markers under Micro and Partial Gravity Loading Conditions

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Extent, Causes, and Countermeasures of Impaired Fracture Healing in Hypogravity

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone

Space Radiation and Bone Loss: Lunar Outpost Mission Critical Scenarios and Countermeasures

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Maintaining Musculoskeletal Health in the Lunar Environment

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Space Radiation Risk Assessment Project-Cucinotta

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Early Markers of Space-Radiation Induced Human Cataractogenesis

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Effects of Estrogen on Cataract Induction After Exposure to High LET Radiation

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Human endothelial cells in 2-D and 3-D systems; non-cancer effects and space-related radiations

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Mechanisms, early events, and dose dependence of radiation-induced atherosclerosis

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Ionizing Radiation and its Effects on Cardiovascular Function in the Context of Space Flight

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Combined Scanning Confocal Ultrasound Diagnostic and Treatment System for Bone Quality Assessment and Fracture Healing

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Reusable Handheld Electrolytes and Lab Technology for Humans

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

A Metabolomics and Mouse Models Approach to Study Inflammatory and Immune Responses to Radiation

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Oxidative Stress and Skeletal Health with Low Dose, Low LET Ionizing Radiation

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Non-Invasive Early Detection and Molecular Analysis of Low X-ray Dose Effects in the Lens

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Pilot Studies of Radiation Damage in Organ Tissues of Mice

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Cardiovascular Imaging and Strategies to Mitigate the Risk for Cardiac Events in Astronauts During Prolonged Spaceflight (Cardiac Risk-Imaging -- Levine, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Impact of Long Duration Space Flight On Cardiac Structure and Function (Long Duration-Cardiac -- Thomas, Active)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Retrospective Study of Serum Sclerostin Measurements in Bedrest Subjects

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Evaluation of Space Radiation-induced Myocardial and BM-derived EPC Damage and Assessment of Associated Long-term Degenerative Cardiovascular Risks

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Effects of Intestinal Microflora on High-LET Radiation Mediated Toxicity and Genomic Instability

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Pharmaceutical Countermeasure Effects on Tissue-level Quality of Immobilized Bone

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 7: We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight.

Simulated Microgravity and Radiation-Induced Bone Degeneration: Oxidative Stress- and p53-Dependent Mechanisms

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

Factors Contributing to Food Acceptability and Consumption, Mood, and Stress on Long-term Space Missions/Food Variety in Free-Living Adults

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Dual Use Packaging

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Advanced Cookware and Techniques for Food Preparation at Reduced Pressure and Gravity

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Evaluate Energy Expenditure During Long-duration (>3mo) Missions.

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N7.1: We need to identify the most important nutritional factors for musculoskeletal health.

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N7.1: We need to identify the most important nutritional factors for musculoskeletal health.

Defining the relationship between biomarkers of oxidative and inflammatory stress and atherosclerosis risk in astronauts during and after long-duration spaceflight (Cardio Ox-Lee, Active)

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

Simulated space radiation and weightlessness: vascular-bone coupling mechanisms to preserve skeletal health

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Evaluation of the combined effects of gamma radiation and high dietary iron on oxidative damage and antioxidant status in rats

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

Spaceflight effects on the mouse retina: Histological, gene expression and epigenetic changes after flight on STS-135

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

Evaluation of the effect of short duration spaceflight on hepatic nutrition, oxidative damage, and colon microflora

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Fracture Healing in Haversian Bone under Conditions of Simulated Microgravity

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone

Effects of high dietary heme iron and radiation on cardiovascular function (Radiation/Iron, CVD-Westby, Completed)

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

Combined effects of gamma radiation and high dietary iron on oxidative damage and antioxidant status in rat eyes

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

Bone Turnover Model: Initial Implementation

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Evaluation of a sclerostin antibody in mice as a novel promoter of bone formation during spaceflight

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Molecular mechanisms underlying heart failure and arrhythmias in astronauts (1-year NSBRI Postdoctoral Fellowship) (Molecular Arrhythmias-Gershovich/Werhans, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

Non-Thermal Sanitation By Atmospheric Pressure Plasma

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Induction of Early Stages of Osteoarthritis After Exposure to Microgravity (NSBRI Postdoctoral Fellowship)

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Contribution of the Vestibular and Sympathetic Nervous Systems to Space-Induced Bone Loss (NSBRI Postdoctoral Fellowship)

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Developing a new bone medical standard for long-duration astronauts based on bone strength estimated by Finite Element [FE] Modeling

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Effect of Space Radiation on degenerative tissue disease, genetic Instability and Oxidative DNA Damage in Ataxia Telangiectasis Deficient Mice

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Precise Assessment of Prevalence and Progression of Lens Opacities in Astronauts as a Function of Radiation Exposure During Space Flight and Development of Improved Routine Clinical Assessment of Ocular Lens Status

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Mechanisms of Ocular Cataracts

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Increasing the Efficiency of Exercise Countermeasures for Bone Loss

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Nutritional countermeasures to ameliorate losses in muscle mass and function

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N7.1: We need to identify the most important nutritional factors for musculoskeletal health.

A Low Intensity Mechanical Countermeasure to Prohibit Osteoporosis in Astronauts During Long-Term Spaceflight

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 7: We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight.

Low Dose Radiation Cataract

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

A Scanning Confocal Acoustic Diagnostic System for Non-Invasively Assessing Bone Quality

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Examination of Anti-Resorptive and Anabolic Treatments/Stimuli on Unloading Induced Osteoporosis

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Bone Recovery Potential After Bisphosphonate and PTH Treatment of Disuse Osteoporosis

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Echocardiographic Assessment of Cardiovascular Adaptation and Countermeasures in Microgravity (Cardio Adaptation-Thomas, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Retention of Skeletal, Musculature, and Postural Status with a Non-invasive, Extremely Low-level Mechanical Signal: A Ground-based Evaluation of Efficacy

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 7: We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight.

Risk of visual impairment and intracranial hypertension after space flight: Evaluation of the role of polymorphism of enzymes involved in one-carbon metabolism [ONE-CARBON METABOLISM/SMITH/COMPLETED]

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Concordia: D, Immune and Metabolism

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Space Biochemistry Profile

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N7.1: We need to identify the most important nutritional factors for musculoskeletal health.

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Nutrition/Pharm Interactions

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Stable Calcium Isotopes in Urine as a Biomarker of Bone Mineral Balance in Spaceflight

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N7.1: We need to identify the most important nutritional factors for musculoskeletal health.

Proteomic Profiling of Human Heart Tissue Exposed to Microgravity (Proteomic Heart-Bowles, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Integrative physiology of VIIP: cardiopulmonary, sleep, and cognitive function assessment during hypercapnic bed rest [Thirty-day CO2 Bedrest/LAURIE/ACTIVE]

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Novel Double-Hit Mouse Model to Investigate Oxidative Damage from Radiation/ Hyperoxia Related to Space Exploration - Evaluation of Dietary Flaxseed as Countermeasure

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Microgravity Associated Compartmental Equilibration (MACE) [FLUID SHIFTS / DULCHAVSKY / ACTIVE]

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Fluid Distribution before, during and after Prolonged Space Flight-NNX13AJ12G [FLUID SHIFTS / HARGENS / ACTIVE]

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Distribution of Body Fluids during Long Duration Space Flight and Subsequent Effects on Intraocular Pressure and Vision Disturbance [FLUID SHIFTS / STENGER / ACTIVE]

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Targeting NO/IKK Signaling to Counteract Hemodynamic Flow-Dependent Endothelial Dysfunction and Vascular Damage after Space Radiation (Endothelial Dysfunction SR-Natarajan, Active)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Stabilized Foods for Use in Extended Spaceflight: Preservation of Shelf-Life, Nutrient Content and Acceptability

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Integrated Resistance and Aerobic Exercise Training with Small Compact Exercise Equipment

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 7: We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight.

Suited Contingency Ops Food - 2

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Astronaut Bone Medical Standards Derived from Finite Element [FE] Modeling of QCT Scans from Populations Studies

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 7: We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight.

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Understanding Kinetics of Nutrient Degradation in Foods-2

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Digital Astronaut: Bone Remodeling Model

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Recovery of Functional Performance Following Long Duration Space Flight (Reschke)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Lab Analysis Point-of-Care Device Evaluation and Downselect (TBD)

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Literature review of factors affecting food and nutrient stability

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Bioavailability of Nutrients in Food

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Packaging Configuration

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Prepackaged Food System Database

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Trade Space Develop

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Trade Methodology Recommendations

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Food Fortification Stability Study

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Functional Foods Baseline and Requirements Analysis

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

New Crop Testing: Nutritional & Organoleptic Analysis

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Data Mining for Bone Research and Clinical Advisory Panel (RCAP)

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Delivery of Probiotics in the Space Food System

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Can Benefits from a Single Administration of Bisphosphonates Extend to a Second Later Exposure to Microgravity?

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 7: We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight.

Effects of Angiotensin Converting Enzyme Inhibitors on Bone Turnover

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 7: We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight.

Radiation Induced Cardiovascular Oxidative Stress: Thiol Modification of Proteins and Novel and Sensitive Biomarkers (Thiol Mod-Berkowitz, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

The Development of a NASA/NSBRI Risk Calculator to Estimate the Short Term Risk of an Acute Coronary Event in Astronauts (CHARM-Khera, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

(NEEMO Nut ROI) Oxidative Damage During a 12-day Saturation Dive

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

The Effects of Space Radiation on Stem Cells and Vascular and Cardiac Disease

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Radiation-Induced Early Changes in Gene and Protein Expression, Lipid Oxidative States, and Vascular Function Related to Atherosclerosis

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

The Role of Oxidative Stress and Inflammation on Synaptic Functions After Exposure to Space Radiation

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Effect of low shear modeled microgravity (LSMMG) on the probiotic Lactobacillus acidophilus ATCC 4356

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Meal Replacement Mass Reduction and Integration Acceptability Study

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Pick-and-Eat Salad-Crop Productivity, Nutritional Value, and Acceptability to Supplement the ISS Food System

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Pick and Eat Crop Selection Study

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Dwarf Fruit Production Study

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Pick and Eat Salad Crop Testing

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Precise Automated Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Surface Food System - Surface Crop Expansion Beyond Pick and Eat

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Sustained Veggie Ground and Flight

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Surface Food System - Processing and Preparation

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Surface Food System - Ingredient Functionality/Formulation

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Influence of Exercise Modality on Cerebral-Ocular Hemodynamics and Pressures [EXERCISE MODALITY/SCOTT/ACTIVE]

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Effects of short term hypercapnia during head-down tilt on ocular structures, cerebral blood flow, and visual acuity in healthy human subjects [CO2 TILT/LAURIE/ACTIVE]

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Vertebral strength and fracture risk following long duration spaceflight

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Improving CV Risk Prediction -- Biomarkers and Beyond, Implications for Astronaut Selection and Monitoring During Prolonged Spaceflight (CV BIOMARKERS / DE LEMOS / ACTIVE)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

Biochemical Occupational Surveillance

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N7.1: We need to identify the most important nutritional factors for musculoskeletal health.

Optimal Nutrition Occupational Surveillance

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N7.1: We need to identify the most important nutritional factors for musculoskeletal health.

Skeletal Responses to Long-Duration Simulated Microgravity in Male and Female Rats (Globus)

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Spinal Structure and Function after 90 Days Long-Duration Simulated Space Flight and Recovery

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Sclerostin's role in regulating bone formation during long-term simulated microgravity and subsequent recovery (Bloomfield)

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Assessment of Structural and Functional Knee Joint Degradation During Modeled Spaceflight

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Effect of Unloading on the Structure and Mechanics of Rotator Cuff Tendon-to-Bone Insertion

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Whole Joint Health: Investigating Modeled Spaceflight Changes in Mice (Postdoctoral Fellowship)

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 7: We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight.

Deep Space Exploration Atmosphere Effects on Hematologic, Immunologic, and Oxidative Stress and Damage Parameters in Astronauts: An ISS Flight Study

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Combined Effects of Space Radiation and Microgravity on the Function of Human Capillaries and the Endothelial Barrier: Implications for Degenerative Disorders

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

Development of a Flow-Perfused and Immunocompetent 3-D Vascular Model for Radiation Risk Assessment of Cardiovascular Disease and Countermeasure Screening

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Determination of risk for and occurrence of heart disease from space radiation

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Long-Term Effect of Space Radiation on Cardiomyocyte Turnover

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Space Radiation Risk Assessment Project

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone

Astronaut Bone Medical Standards Derived from Finite Element (FE) Modeling of QCT Scans from Population Studies and Astronauts (Phase II)

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 7: We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight.

2022 NSCOR: CVD/Late CNS clinical MCM Assessment

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-202: Develop and ground-test countermeasures against the spaceflight-induced changes in the cardiovascular system of importance for development of disease.

2026 NSCOR: CVD/Late CNS MCM Assessment: Combined Spaceflight Stressors

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-202: Develop and ground-test countermeasures against the spaceflight-induced changes in the cardiovascular system of importance for development of disease.

Improvement of Shelf Life for Space Food Through Hurdle Approach

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Evaluation of an Impedance Threshold Device as a Vision Impairment and Intracranial Pressure (VIIP) Countermeasure [IMPEDANCE THRESHOLD COUNTERMEASURE/EBERT/ACTIVE]

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Integrated Cardiovascular (ICV) 2.0: Assessing the Risk for Atrial Fibrillation in Astronauts During Long Duration Spaceflight [INTEGRATED CARDIOVASCULAR 2/LEVINE/ACTIVE]

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Biomarker Assessment for Identifying Heightened Risk for Cardiovascular Complications During Long-Duration Space Missions [IMAGING AND OMICS - CV RISK/LINDNER/ACTIVE]

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Bioregenerative Food System Database

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

High-Protein And Polyphenol Bar Formulations: Utilizing Whey Protein-Polyphenol Ingredients

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

The Integrated Impact of Diet on Human Immune Response, the Gut Microbiota, and Nutritional Status During Adaptation to Spaceflight

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Center for Research on Cardiac and Vascular Effects of Space Radiation

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-202: Develop and ground-test countermeasures against the spaceflight-induced changes in the cardiovascular system of importance for development of disease.

VIIP and One-Carbon Metabolism: Expanded Polymorphism Evaluation and Polycystic Ovary Syndrome Pilot Study [1C-PCOS/SMITH/ACTIVE]

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Million Worker and Veteran Study

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Individual Differences in the Neuronal and Behavioral Response to Exposure to HZE Particles

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Proteomic Signatures of Space Radiation Induced Cardiovascular Degeneration

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Mars 600/900 Simulation I: Large Animal Chronic Studies

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Omics and biochemical markers of cardiovascular and bone health: Relationship with bedrest and standard physiological measures

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Risk of Spaceflight Induced Cardiovascular Disease

Identification of functional metabolomic alterations during the simulated spaceflight environment. (Rana)

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Risk of Spaceflight Induced Cardiovascular Disease

Identification of Functional Metabolomic Profiles Contributing to Physiological Adaptations to Simulated Spaceflight. (Rana)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

An Integrated Framework for Characterization of the Noncoding Genome and Epigenome in Astronauts (Mason)

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Gravitational dose and multi-system physiologic response

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Center for Medical Countermeasures II – Cross Risk

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Food Radiation Validation FTO

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

2022 NSCOR-CVD/Late CNS: Impact of Combined Spaceflight Stressors

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

Mars 600/900 Simulation II: Large Animal Chronic Studies

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Mitigating radiation-induced bone loss via dietary modulation of inflammatory cytokines (Bloomfield)

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-202: Develop and ground-test countermeasures against the spaceflight-induced changes in the cardiovascular system of importance for development of disease.
	Osteo 7: We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight.

Musculoskeletal response to a partial-gravity analog in rats: structural, functional and molecular alterations (Rutkove)

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 7: We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight.

VIIP Simulations of CSF, Hemodynamics and Ocular Risk (OPHTHALMIC MODELING CHANGES 2)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Food Acceptability, Menu Fatigue, and Aversion on ISS Missions

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Baseline Microbial Assessment of Fresh Produce

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Effects of chronic and single-dose charged particle exposure on cardiac function and structure in multiple animal models

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Degenerative Cardiovascular Disease Risks Due to Single HZE or Mixed Ion Radiation

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Tissue Sharing Project-Effects of space radiation on the cardiac mitochondrial stress response

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Attenuation of Space Radiation-induced Pro-oxidant and Fibrotic Signaling in the Heart by Nutritional and Genetic Interventions: Adventures in Tissue Sharing

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-202: Develop and ground-test countermeasures against the spaceflight-induced changes in the cardiovascular system of importance for development of disease.

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

2020 Cross-Species Rodent ISS Study: CVD/late CNS Clinical Model #1 (chronic study)

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.
	CVD-202: Develop and ground-test countermeasures against the spaceflight-induced changes in the cardiovascular system of importance for development of disease.

Galactic Cosmic Ray Simulator and Mitigation Project

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

GCR Simulation Dose Rate Studies

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Multi-Model Ensemble Risk Assessment

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Inter-Agency Medical Countermeasures Studies

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-202: Develop and ground-test countermeasures against the spaceflight-induced changes in the cardiovascular system of importance for development of disease.

Contracted Study CM Validation II (Cross Risk)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-202: Develop and ground-test countermeasures against the spaceflight-induced changes in the cardiovascular system of importance for development of disease.

Space Relevant Radiation-Induced Cardiovascular Disease Risk Thresholds: Effect of Gender on the Outcome

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Sex- and Apo E-specific late CNS and cardiovascular effects of space radiation

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Imaging and Serum Biomarkers to Predict and Identify Early Cardiac Injury from Radiation Exposure

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Quantitative Imaging and Biofluid Biomarkers Predictive of Cognitive Toxicity and Cerebro-/Cardiovascular Pathologies following Brain Irradiation

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

CBS VNSCOR #1: Responses of the Nervous System to Chronic, Low Dose Charged Particle Irradiation

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

BioNutritional Countermeasures Data Mining

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Identification, Development, and Validation of Countermeasures to Counter Synergistic Effects of Space Radiation on CNS/BMed/SM (CBS) Risk Areas (NRA)

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

A determination of bioactive proteins secreted by the human vasculature in response to low dose space radiation

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Predictive Biomarkers for Space Radiation Induced Cancer and Cardiovascular Injury Risk Assessment

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Quantitative Microbial Risk Assessment: Exploring the Microbiome at the International Space Station to Develop Food Production Systems

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Space Food System Microbial Requirements Development

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Molecular-based Environmental Microbial Monitoring of Cropped Based Food System

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Understanding Kinetics of Nutrient Degradation in Foods-3

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

[SMT] Exploration Food System Program Evaluation

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Produce Safety Methods

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

GMO Crops

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Advanced Crop Hardware Testing

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Effect of Simulated Solar Particle Events and Galactic Cosmic Rays on Crop Growth and Development

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Effects of low-dose radiation on neurovascular remodeling and blood-retina barrier function in mice, rats and rabbits

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Gamma-tocotrienol as a countermeasure against high-energy charged particle-induced carcinogenesis, cardiovascular disease, and central nervous system effects

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-202: Develop and ground-test countermeasures against the spaceflight-induced changes in the cardiovascular system of importance for development of disease.

Telomeres and the One Year Mission Project

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Defining the relationship between simulated weightlessness and space radiation on cardiovascular disease, and the effectiveness of a countermeasure

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

Countermeasures to Radiation Induced Cardiomyopathy

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

EVALUATING RESISTIVE EXERCISE AS A LONG-TERM COUNTERMEASURE FOR SPACEFLIGHT-INDUCED BONE LOSS USING CALCIUM ISOTOPES (Romaniello)

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Temporal changes in astronauts muscle and cardiorespiratory physiology pre, during, and post spaceflight (Downs)

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	Risk of Spaceflight Induced Cardiovascular Disease
	N7.1: We need to identify the most important nutritional factors for musculoskeletal health.

Variation in CNS damage signaling and blood sentinels of neuropathology after exposure to space radiation.

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Effects of Spaceflight Durations up to One Year in Low Earth Orbit on Cardiovascular Structure and Function in Astronauts

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

Cardiovascular Disease Data Mining Phase II with Cooper Clinic

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Dose-Response Study of Musculoskeletal Outcomes Following Centrifugation in Adult Mice on ISS (Bouxsein)

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Time Course of Spaceflight-Induced Adaptations in Bone Morphology, Bone Strength and Muscle Quality (Bouxsein)

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Ovarian cancer and space radiation

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Supercomputer genomics to help maintain core capability at ARC

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

Assessment of galactic cosmic ray dose rate effects on endothelial function

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-202: Develop and ground-test countermeasures against the spaceflight-induced changes in the cardiovascular system of importance for development of disease.

The Effect of Simulated Space Radiation on the Interaction of the Metabolome, Immune System and Lymphatic Anatomy of the Gastrointestinal Tract

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Cardiovascular responses to simulated spaceflight: molecular signatures and surrogate outputs to measure CVD risk.

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

The impact of human spaceflight on clonal hematopoiesis

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

Characterization of Jugular Venous Blood Flow during Acute Fluid Shifts

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Bacillus spore probiotics: evaluation of survival and efficacy after exposure to deep-space radiation simulating long-duration human exploration missions

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Printed Electrochemical Sensor Strip for Quantifying Bone Density Loss in Microgravity (Koehne)

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Microgreens Nutritional Investigation

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Coronary Anatomy and Physiology During 1 Year in Space - ISS

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

The Integrated Impact of Diet on Human Immune Response, the Gut Microbiota, and Nutritional Status During Adaptation to Spaceflight 2 (HRP Funded)

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Rat Radiation + ISS Flight

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

CVD Monitoring on Deep Space Gateway

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

Rodent Lunar Stays

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

Rat Countermeasure Radiation + ISS Flight

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

CVD Integrated Flight Countermeasure Study on ISS

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

CVD Integrated Flight Countermeasures Study for Deep Space Gateway and Lunar

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Development for Rodent Lunar Stays - Lab

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

Potential Role of the Endothelium in Internal Jugular Venous Thrombosis due to Abnormal Venous Flow Patterns During Spaceflight

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Thrombosis Countermeasures - ISS

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease