Task Computational Model Prediction & Biological Validation using Simplified Mixed Field Exposures for the Development of a GCR Reference (Completed)
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: GCR Computational Modeling
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:

Aim 1: To evaluate the effects of dose rate on biological damage, the investigators will use acute and chronic exposures with single ion and mixed field beams to irradiate normal human fibroblasts and measure chromosome aberrations. RITRACKS and BDSTracks will be used to model existing and newly collected experimental datasets.

 

Aim 2: To compare the external field versus local tissue field approach, the investigators will measure

chromosome aberrations in normal human fibroblasts using shielded and unshielded single and mixed field beams. These data will help determine if the two approaches produce similar biological responses to the simulated GCR environments.

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