Short Title:
MASS
Responsible HRP Element:
Human Health Countermeasures
Funding Status:
Terminated - A formerly active task that was stopped before its completion date due to deselection, descoping, reorganization etc.
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Procurement Mechanism(s):
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Aims:
DESCOPED and then DEFUNDED due to a shift in strategic planning.
The aim is to develop a multiscale computational model that can predict changes in muscle structure and function in response to both microgravity and in-flight exercise. The modeling approach will provide a cohesive, user-friendly, and open-source framework for computational simulations at different levels of spatial scale, including: dynamic OpenSim simulations at the whole body level; finite-element simulations of muscle tissue; and agent-based simulations of muscle cells that include the biochemical and biomechanical processes that drive individual muscle cell adaptations. This level of integration is necessary because factors at all of these scales influence the degree of muscle atrophy during prolonged spaceflight but they have never been considered in isolation.
Category:
Technology or Tool
Subcategory:
Computational Models or Simulations
Description:
Deliverables include the software source code and dcumentation that describes the modeling approaches used, as well as a model operations guide.
The model will integrate with OpenSim biomechanics simulation software and will be quantitatively verified and validated following the standard of NASA-STD-7009.
Internal Customers:
None
External Customers:
None