Task VIIP Simulations of CSF, Hemodynamics and Ocular Risk (OPHTHALMIC MODELING CHANGES 2)
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: Ophthalmic Modeling Changes 2
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:

 The aim is to develop modeling tools that: (i) compute fluid shifts in microgravity; (ii) compute how these shifts lead to biomechanical insult to the optic nerve in astronauts; and (iii) estimate the effect that these insults have on optic nerve function. These tools will directly build upon, and interface with, models of ocular biomechanics and fluid shifts that are currently being developed in

the NASA-funded MONSTR Sim project. Four specific aims were proposed:

SA1: Measure key physiologic parameters needed for modeling, including effects of intracranial pressure on optic nerve sheath

diameter, optic nerve tortuosity, craniospinal volume and cerebral blood flow.

SA2: Incorporate “quasi-1D” effects into existing compartment models, allowing us to evaluate the effects of microgravity and

countermeasures on CSF and blood flows/pressures.

SA3: Extend finite element models of ocular biomechanics, specifically modeling: (i) optic nerve kinking, and (ii) compression of optic

nerve fiber bundles in the lamina cribrosa; and relate kinking/compression to an index of axoplasmic insult/stasis.

SA4: Carry out parametric studies integrating the above models to identify individual-specific factors that: (i) predispose for the

development of VIIP syndrome, and (ii) influence the efficacy of proposed countermeasures, both useful for risk profiling


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