HRR - Task - Effects of chronic and single-dose charged particle exposure on cardiac function and structure in multiple animal models

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Effects of chronic and single-dose charged particle exposure on cardiac function and structure in multiple animal models (Completed)

Last Published: 04/20/22 11:43:24 AM (Central)

Task Book: Entry
Principal Investigator: Boerma, Marjan

Short Title: Tissue-Multiple Animal Models

Responsible HRP Element: Space Radiation

Collaborating Org(s):

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Solicited

Aims:

Aim 1: Determine the effects of chronic low-dose rate neutron exposure on cardiac function and structure in male C3H and female BALB/c mice.

Aim 2: Assess how Long Evans rats scale to C3H and BALB/c mice in their cardiovascular response to chronic low-dose rate neutron exposure.

Aim 3: Identify similarities and differences in the cardiovascular response to low dose protons and 16O exposure in the mouse, rat, and rabbit.

Resources (None Listed)

Deliverables (1)

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:
Annual and final reports. The overall goal of this study is to provide insight into the effects of chronic low-dose rate high-LET radiation exposures on the heart and to identify how animal species differ in their response to high-LET radiation.

Internal Customers:
None External Customers:
None

Mappings

Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Effects of chronic and single-dose charged particle exposure on cardiac function and structure in multiple animal models

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Risk Approach Plans (1)

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Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes