Task Degenerative Cardiovascular Disease Risks Due to Single HZE or Mixed Ion Radiation
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: Tissue-CV HZE or Mixed Ion
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:

Aim 1: In the archived heart samples of fractionated proton and iron IR studies the study

plans to determine long-term IR-induced effects on cardiac fibrosis, inflammation, oxidative damage, microvascular, structural and morphological changes in the heart, including cellular hypertrophy and cytoskeletal reorganization.

 

Aim 2: In archived samples of CB6F1 mice irradiated with a range of low and very low doses of gamma, 14Si, 22Ti and 56Fe the study proposes to determine long-term effects and molecular endpoints in the heart as a function of IR type and dose.

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