HRR - Task - 2020 Cross-Species Rodent ISS Study: CVD/late CNS Clinical Model #1 (chronic study)

Efficacy of Vitamin D Supplementation in an Antarctic Ground Analog of Space Flight

Common Item(s)
	Risk of Inadequate Nutrition

Vitamin D Supplementation in an Antarctic Ground Analog of Space Flight: Study of Supplementation Protocol and Relationship to Immune System Function

Common Item(s)
	Risk of Inadequate Nutrition

Vitamin D Supplement Evaluation of Dosing Requirements

Common Item(s)
	Risk of Inadequate Nutrition

Nutritional Status Assessment: SMO-016E

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	Risk of Inadequate Nutrition
	IM8: We do not know the influence, direct, or synergistic, on the immune system of other physiological changes associated with spaceflight.
	N15: We need to identify the most important nutritional factors for oxidative damage during spaceflight.

Dietary Intake Can Predict and Protect Against Changes in Bone Metabolism During Space Flight and Recovery (Pro-K)

Common Item(s)
	Risk of Inadequate Nutrition

Characterization of Oxidative Damage During a Saturation Dive

Common Item(s)
	Risk of Inadequate Nutrition
	N15: We need to identify the most important nutritional factors for oxidative damage during spaceflight.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Inadequate Nutrition
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.
	N15: We need to identify the most important nutritional factors for oxidative damage during spaceflight.

Cardiac Atrophy and Diastolic Dysfunction During and After Long Duration Spaceflight: Functional Consequences for Orthostatic Intolerance, Exercise Capacity, and Risk of Cardiac Arrhythmias (ICV-Bungo/Levine, Active)

Common Item(s)
	Risk of Cardiac Rhythm Problems

Animal radiation study (Radiation Pilot-Westby, Completed)

Common Item(s)
	Risk of Cardiac Rhythm Problems
	CV8: Can manifestations of sub-clinical or environmentally induced cardiovascular diseases during spaceflight be predicted?

Bracelet Investigation (Brazlet Dulchavsky, Completed)

Common Item(s)
	Risk of Cardiac Rhythm Problems

Validation of On-Orbit Methodology for the Assessment of Cardiac Function and Changes in the Circulating Volume Using Ultrasound and Braslet-M Occlusion Cuffs, SDTO 17011 U/R (Braslet-M -- Duncan, Completed)

Common Item(s)
	Risk of Cardiac Rhythm Problems

The impact of modeled microgravity and prior radiation exposure on cytomegalovirus reactivation and host immune evasion

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

The Multisystem Effect of Exercise Training/Nutritional Support During Prolonged Bed Rest Deconditioning: An Integrative Approach to Countermeasure Development for the Heart, Lungs, Muscles and Bones (Integrative CM-Levine, Completed)

Common Item(s)
	Risk of Cardiac Rhythm Problems

Microbial Risk Assessment and Integration

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM8: We do not know the influence, direct, or synergistic, on the immune system of other physiological changes associated with spaceflight.

Immune Countermeasures Validation (Analog)

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Validation of Procedures for Monitoring Crewmember Immune Function (Integrated Immune - SMO 015/SDBI 1900) Completed

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Flight-Induced Changes in Immune Defenses-DSO 498

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Incidence of Latent Virus Shedding During Space Flight-DSO 493

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Space Flight-Induced Reactivation of Latent Epstein-Barr Virus

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Immune Function Changes During a Spaceflight-analog 12-day Undersea Mission (NEEMO IIH ROI)

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

3D Tissue Analogs for the Study of Varicella-Zoster Virulence and Infectivity

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Apoptosis and Immune Homeostasis During Hindlimb Unloading

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Consequences of Long-term Confinement and Hypobaric Hypoxia on Immunity in the Antarctic Concordia Environment (CHOICE)

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Dose Tracker Application for Monitoring Crew Medication Usage, Symptoms and Adverse Effects During Missions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Identification of cardiometabolic vulnerabilities caused by effects of synergistic stressors that are commonly encountered during space missions (Cardiometabolic Vulnerabilities-Shea, Active)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Adverse Health Event Due to Altered Immune Response
	Risk of Cardiac Rhythm Problems
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.
	CV8: Can manifestations of sub-clinical or environmentally induced cardiovascular diseases during spaceflight be predicted?
	IM8: We do not know the influence, direct, or synergistic, on the immune system of other physiological changes associated with spaceflight.

Data Mining for Incidence of Renal Stone Formation Following Spaceflight

Common Item(s)
	Risk of Inadequate Nutrition

Renal Stone Risk during Spaceflight: Assessment and Countermeasure Validation (Renal Stone - DSO 633)

Common Item(s)
	Risk of Inadequate Nutrition

Effects of emotional stress on the cardiovascular system (Stress and CV Health-TBD, Planned)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Cardiac Rhythm Problems
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.
	CV8: Can manifestations of sub-clinical or environmentally induced cardiovascular diseases during spaceflight be predicted?

Determining the Effect of Space Flight on the Incidence of Cardiovascular Risk Factors and Disease (CV Data Mining-Barstow, Active)

Common Item(s)
	Risk of Cardiac Rhythm Problems
	CV8: Can manifestations of sub-clinical or environmentally induced cardiovascular diseases during spaceflight be predicted?

Effects of Retronasal Smelling, Variety, and Choice on Appetite and Satiety

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Sensorimotor Assessment and Rehabilitation Apparatus: Procedures and Equipment (Schubert)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Robust Human-System Interface Design for Spaceflight-Induced Environments (Interface Design-Stone, Completed)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Temperature Regulatory and Cardiovascular Responses to Exercise During Long-Duration Spaceflight

Common Item(s)
	Risk of Cardiac Rhythm Problems
	CV8: Can manifestations of sub-clinical or environmentally induced cardiovascular diseases during spaceflight be predicted?

DEFERRED: Validation of Exploration Atmosphere Prebreathe Protocol

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Inadequate Nutrition
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.
	N15: We need to identify the most important nutritional factors for oxidative damage during spaceflight.

Physiological Factors Contributing to Postflight Changes in Functional Performance (Bloomberg)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Development of Countermeasures to Enhance Sensorimotor Adaptation (Bloomberg)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Assessment of Operator Proficiency Following Long-Duration Spaceflight (Moore)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.
	Sleep Gap 2: We need to understand the contribution of sleep loss, circadian desynchronization, extended wakefulness and work overload, on individual health (physical and behavioral), team functioning, and performance (including operational performance), for spaceflight.

Galvanic Vestibular Stimulation (GVS) as an Analogue of Post-flight Sensorimotor Dysfunction (Moore)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Integrated Nutrition: Development and Provision of Functional Foods to Mitigate Bone Loss on ISS Missions

Common Item(s)
	Risk of Inadequate Nutrition
	N15: We need to identify the most important nutritional factors for oxidative damage during spaceflight.

Sensorimotor Displays and Controls to Enhance the Safety of Human/Machine Cooperation During Lunar Landing (Lander D&C-Young, Completed)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Advanced Displays for Efficient Training and Operation of Robotic Systems (Robotic Systems-Oman, Completed)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Development of Countermeasures to Aid Functional Egress from the Crew Exploration Vehicle Following Long-Duration Spaceflight (Mulavara)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Recovery Data Mining: Relationship Between In-Flight Exercise and Postflight Sensorimotor Performance. (Reschke)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Performance Data Mining: Correlation Between Previous Performance Data with Clinical Observations. (Reschke)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Spaceprint: Development and Validation of a Tool to Predict, Evaluate, and Mitigate Excessive Workload Effects

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Space Radiation Risk Assessment Project-Cucinotta

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors

Early Markers of Space-Radiation Induced Human Cataractogenesis

Common Item(s)
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors

Effects of Estrogen on Cataract Induction After Exposure to High LET Radiation

Common Item(s)
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Degen - 6: What are the most effective medical or dietary countermeasures to mitigate degenerative tissue risks? Are there common pathways that will benefit multiple tissues?

Human endothelial cells in 2-D and 3-D systems; non-cancer effects and space-related radiations

Common Item(s)
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors

Mechanisms, early events, and dose dependence of radiation-induced atherosclerosis

Common Item(s)
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors

Ionizing Radiation and its Effects on Cardiovascular Function in the Context of Space Flight

Common Item(s)
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Sensory Stimulation Augmentation Tools (RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Hybrid Training - A Sensory Stimulation Countermeasure for Long Duration Space Exploration Missions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Psychomotor Vigilance Test (PVT) on ISS

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	Sleep Gap 2: We need to understand the contribution of sleep loss, circadian desynchronization, extended wakefulness and work overload, on individual health (physical and behavioral), team functioning, and performance (including operational performance), for spaceflight.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Promoting stress tolerance, adaptability and behavioral health via enhancing exercise protocols for LDEM

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Objective Detection, Evaluation and Countermeasures for In-flight Depression

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Optical Computer Recognition of Stress, Affect and Fatigue During Performance in Spaceflight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Objective Monitoring of Crew Neurobehavioral Functions (105-day Russian Chamber Study)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Neurobehavioral Conditions List for Exploration Missions (RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Asthenia Literature Review

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Voice Content Analysis Techwatch

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Detection & Prevention of Neurobehavioral Vulnerability to Space Radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Evidence Review: Cognition in Long Duration Missions in Isolated, Confined and Extreme Environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Validation of Assessment Tests and Countermeasures for Detecting and Mitigating Changes in Cognitive Function During Robotics Operations

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.
	Sleep Gap 2: We need to understand the contribution of sleep loss, circadian desynchronization, extended wakefulness and work overload, on individual health (physical and behavioral), team functioning, and performance (including operational performance), for spaceflight.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Integrated Cognitive Assessment: Combining Measurement, System, and Mission

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Neurostructural, Cognitive, and Physiologic Changes During a 1-year Antarctic Winter-Over Mission

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Cognitive Performance and Stress in a Simulated Space Environment

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	Sleep Gap 2: We need to understand the contribution of sleep loss, circadian desynchronization, extended wakefulness and work overload, on individual health (physical and behavioral), team functioning, and performance (including operational performance), for spaceflight.

The Prediction of the Onset of Anxiety Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

White Paper on the Onset of Depression

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Meta-Analysis of the effects of ICE environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Evidence Review on Identification of Psychosocial Characteristics in ICE Environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Growth and Resilience for Long Duration Exploration Missions(RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Effects of Well-Being on Performance in ICE Environments (RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Individual differences and adaptation to Isolated, Confined, and Extreme (ICE) environments (Research Requirements)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Self-Guided Depression Treatment on Long-Duration Spaceflights

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

A Multi-Media, Computer-Based, Self-Directed, Autonomous, Stress and Anxiety-Management Countermeasure

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Behavioral Issues Associated with Long Duration Space Missions: Review of Astronaut Journals

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Asynchronous Behavioral Health Treatment Techniques

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Immune Function Data Mining

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Sleep-Wake Actigraphy and Light Exposure During Spaceflight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Environmental Factors Evidence Review

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Transition Actiwatch Protocol to Medical Operations

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

The Biological Basis of Emotional Support for Long Duration Exploration Missions (RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Determine best methods to maintain contact with astronaut social support network during pre-mission training (RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Techwatch for Sleep Monitoring Technologies for Long Duration Spaceflight

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Evidence Review on Biomarkers of Individual Vulnerabilities to Sleep Loss and Circadian Desynchronization

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

AD ASTRA: Automated Detection of Attitudes and States through Transaction Recordings Analysis

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Team Risk Standardized Measures Workshop

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Operational Evaluation of Photic Countermeasure to Improve Alertness, Performance, and Mood during Nightshift Work on a 105-Day Study (105-day Russian Chamber Study)

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Countermeasure for Managing Interpersonal Conflicts in Space: A Continuation Study

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

ANSIBLE: A Network of Social Interactions for Bilateral Life Enhancement

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Dynamic Team Role Allocation in Long Duration, Exploration Missions: Identification of Roles, Triggers, and Measurement Tools

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Evaluation of Photic Countermeasures for Circadian Entrainment of Neurobehavioral Performance and Sleep-Wake Regulation Before and During Spaceflight

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Optimizing Light for Long Duration Space Exploration

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Blue Light for Enhancing Alertness in Space Missions

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Characteristics of Light Exposure Necessary for Development of Optimal Countermeasures to Facilitate Circadian Adaptation and Enhance Alertness and Cognitive Performance in Space

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Feasibility Pilot Study on Acute Biological and Behavioral Responses to the Solid State Lighting Modules for the International Space Station

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Testing solid state lighting countermeasures to improve circadian adaptation, sleep, and performance during high fidelity analog and flight studies for the International Space Station

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Develop and Implement Operational Ground Testing Protocols to Individualize Astronaut Sleep Medication Efficacy and Individual Effects (pilot study)

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Operational Ground Testing Protocols to Individualize Astronaut Sleep Medication Efficacy and Individual Effects

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	Sleep Gap 2: We need to understand the contribution of sleep loss, circadian desynchronization, extended wakefulness and work overload, on individual health (physical and behavioral), team functioning, and performance (including operational performance), for spaceflight.

Designing Individual Countermeasures to Reduce Sleep Disruption and Improve Performance and Alertness in Space

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Physiologically-Based Modeling of Sleep-Wake Scheduling and the Effects of Pharmaceuticals (NSBRI Postdoctoral Fellowship)

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Countermeasures for Performance Deficits from Sleep Loss and Workload in Space Flight

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Individualized Fatigue Meter for Space Exploration (SBIR Phase II)

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Countermeasures to Neurobehavioral Deficits from Cumulative Sleep Deprivation During Space Flight: Dose-Response Effects of Recovery Sleep Opportunities

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Survey of On-Orbit Sleep Quality (Sleep Quality Questionnaire)

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Phoenix Scout Lander: Countermeasures Testbed for Spaceflight Ground Controllers

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

A Comprehensive Fatigue Management Program and an Evaluation of a Photic Countermeasure for Mission Controllers

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Neurodegeneration and Adaptation in Response to Low-Dose Photon Irradiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

A Metabolomics and Mouse Models Approach to Study Inflammatory and Immune Responses to Radiation

Common Item(s)
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors

Oxidative Stress and Skeletal Health with Low Dose, Low LET Ionizing Radiation

Common Item(s)
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors

Non-Invasive Early Detection and Molecular Analysis of Low X-ray Dose Effects in the Lens

Common Item(s)
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors

Proteomic aided investigation of the mechanistic basis for HZE-induced cognitive impairment and the development of diagnostic biomarkers

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

The Impact of HZE Particles on Adult Neural Stem Cells and Neurogenesis

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Epigenetic Control of Radiogenic Damage Processing in C. elegans

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Individual Differences in the Neurochemical and Behavioral Response to Exposure to Protons

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Molecular Basis of DNA Repair and Protection from Apoptosis in Neuronal Progenitors Exposed to Space Radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Local CNS and Systemic Inflammatory Effects Following Proton and Mixed Particle Exposure

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Oxidative stress as a mechanism for altering acute and chronic functional changes in the CNS exposed to low dose, low dose rates, and mixed fields of protons and HZE nuclei

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Use of a molecular marker of learning and memory to assess effects of 56Fe irradiation on hippocampus-dependent cognition and neurogenesis

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Cognitive/Behavioral, Sensory, & Motor Changes Induced by Solar Particle Event (SPE) and Galactic Cosmic Ray (GCR) Irradiations

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

NSCOR: Charged Particle Radiation and Resultant Oxidative Stress Elicit Deleterious Functional Changes in the Central Nervous System

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

High LET-radiation induced DNA repair mechanisms in Oligodendrocyte progenitor cells (OPC) in vitro and in vivo

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Development and use of human 3-Dimensional tissue culture models for the study of space radiation effects on the central nervous system

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Virtual Reality (VR) Technologies for Enhancing Behavioral Health

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Assessing Team Performance in Autonomous Environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Cardiovascular Imaging and Strategies to Mitigate the Risk for Cardiac Events in Astronauts During Prolonged Spaceflight (Cardiac Risk-Imaging -- Levine, Completed)

Common Item(s)
	Risk of Cardiac Rhythm Problems
	CV8: Can manifestations of sub-clinical or environmentally induced cardiovascular diseases during spaceflight be predicted?

Impact of Long Duration Space Flight On Cardiac Structure and Function (Long Duration-Cardiac -- Thomas, Active)

Common Item(s)
	Risk of Cardiac Rhythm Problems

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Evaluation of Space Radiation-induced Myocardial and BM-derived EPC Damage and Assessment of Associated Long-term Degenerative Cardiovascular Risks

Common Item(s)
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors

Effects of Intestinal Microflora on High-LET Radiation Mediated Toxicity and Genomic Instability

Common Item(s)
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors

Effects of Alphalipoic Acid on Irradiation Induced Cognitive Deficits (Postdoctoral Fellowship)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Pharmacology Database

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Simulated Microgravity and Radiation-Induced Bone Degeneration: Oxidative Stress- and p53-Dependent Mechanisms

Common Item(s)
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Degen - 7: Are there synergistic effects from other spaceflight factors (e.g. altered gravity (µ-gravity), stress, altered immune function, altered circadian rhythms, or other) that modify space radiation-induced degenerative diseases in a clinically significant manner?

Individualized Real-Time Neurocognitive Assessment Toolkit for Space Flight Fatigue

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Composing and Developing Resilient, Adaptive, and Self-Sustaining Teams for Long Duration Space Exploration

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Factors Contributing to Food Acceptability and Consumption, Mood, and Stress on Long-term Space Missions/Food Variety in Free-Living Adults

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Spaceflight Effects on Neurocognitive Performance: Extent, Longevity, and Neural Bases (NeuroMapping-Flight-Seidler)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

The Effects of Long-Term Exposure to Microgravity on Salivary Markers of Innate Immunity

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

DEFERRED: Development of an integrated sensorimotor countermeasure suite for spaceflight operations

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Developing Predictors of Sensorimotor Adaptability - ISS Flight Validation (TBD)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Effect of Sensorimotor Adaptation Following Long-Duration Spaceflight on Perception and Control of Vehicular Motion (Wood)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.
	Sleep Gap 2: We need to understand the contribution of sleep loss, circadian desynchronization, extended wakefulness and work overload, on individual health (physical and behavioral), team functioning, and performance (including operational performance), for spaceflight.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Immune Countermeasures Validation - Flight

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Evaluate Energy Expenditure During Long-duration (>3mo) Missions.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Inadequate Nutrition
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.
	N15: We need to identify the most important nutritional factors for oxidative damage during spaceflight.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Inadequate Nutrition
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.
	N15: We need to identify the most important nutritional factors for oxidative damage during spaceflight.

Two-Hit Model of Alzheimer's Disease

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Functional decline in mice with Alzheimer's-type neurodegeneration is accelerated by charge-particle radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Molecular Characterization of Long-term Degenerative CNS Risks from Space Radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Identification of the Changes in the Brain Proteome Associated with HZE-induced Neurocognitive Impairment

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Defining the relationship between biomarkers of oxidative and inflammatory stress and atherosclerosis risk in astronauts during and after long-duration spaceflight (Cardio Ox-Platts, Active)

Common Item(s)
	Risk of Cardiac Rhythm Problems
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Inadequate Nutrition
	CV8: Can manifestations of sub-clinical or environmentally induced cardiovascular diseases during spaceflight be predicted?
	Degen - 7: Are there synergistic effects from other spaceflight factors (e.g. altered gravity (µ-gravity), stress, altered immune function, altered circadian rhythms, or other) that modify space radiation-induced degenerative diseases in a clinically significant manner?

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Multi-Modal Neurodiagnostic Tool for Stress Monitoring

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Individualized Stress Detection System

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	Sleep Gap 2: We need to understand the contribution of sleep loss, circadian desynchronization, extended wakefulness and work overload, on individual health (physical and behavioral), team functioning, and performance (including operational performance), for spaceflight.

Sleep Workshop

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Development and testing of biomarkers to determine individual astronauts' vulnerabilities to behavioral health disruptions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Individualized Behavioral Health Monitoring Tool

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Objective Monitoring of Crew Neurobehavioral Functions in Mars 520-Day Simulation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

CogGauge Enhancement

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

South Pole Station: An Analogue for Human Performance During Long Duration Missions to Isolated and Confined Environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Optical Computer Recognition of Stress, Affect and Fatigue in Space Flight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Self-Guided Multimedia Stress Management and Resilience Training

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Autonomous Behavioral Health Countermeasures for Spaceflight - Virtual Space Station

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Characterize Workload on the International Space Station (ISS) (Research Requirements)

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Evidence Review: long term safety effects of low spectrum light exposure

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	Sleep Gap 2: We need to understand the contribution of sleep loss, circadian desynchronization, extended wakefulness and work overload, on individual health (physical and behavioral), team functioning, and performance (including operational performance), for spaceflight.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	Sleep Gap 2: We need to understand the contribution of sleep loss, circadian desynchronization, extended wakefulness and work overload, on individual health (physical and behavioral), team functioning, and performance (including operational performance), for spaceflight.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Evaluation of the combined effects of gamma radiation and high dietary iron on oxidative damage and antioxidant status in rats

Common Item(s)
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Inadequate Nutrition
	Degen - 7: Are there synergistic effects from other spaceflight factors (e.g. altered gravity (µ-gravity), stress, altered immune function, altered circadian rhythms, or other) that modify space radiation-induced degenerative diseases in a clinically significant manner?
	N15: We need to identify the most important nutritional factors for oxidative damage during spaceflight.

Spaceflight effects on the mouse retina: Histological, gene expression and epigenetic changes after flight on STS-135

Common Item(s)
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Degen - 7: Are there synergistic effects from other spaceflight factors (e.g. altered gravity (µ-gravity), stress, altered immune function, altered circadian rhythms, or other) that modify space radiation-induced degenerative diseases in a clinically significant manner?

Evaluation of the effect of short duration spaceflight on hepatic nutrition, oxidative damage, and colon microflora

Common Item(s)
	Risk of Inadequate Nutrition
	N15: We need to identify the most important nutritional factors for oxidative damage during spaceflight.

Examination of Splenic and Thymic Immune Function in Mice (STS-135 Mouse Tissue Sharing Pilot Study)

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Evaluation of the combined effects of gamma radiation and high dietary iron on oxidative damage and antioxidant status in rats (Immune Assessment)

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM8: We do not know the influence, direct, or synergistic, on the immune system of other physiological changes associated with spaceflight.

Effects of high dietary heme iron and radiation on cardiovascular function (Radiation/Iron, CVD-Westby, Completed)

Common Item(s)
	Risk of Cardiac Rhythm Problems
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Inadequate Nutrition
	CV8: Can manifestations of sub-clinical or environmentally induced cardiovascular diseases during spaceflight be predicted?
	Degen - 7: Are there synergistic effects from other spaceflight factors (e.g. altered gravity (µ-gravity), stress, altered immune function, altered circadian rhythms, or other) that modify space radiation-induced degenerative diseases in a clinically significant manner?

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Effects of Space Radiation on Hippocampal-Dependent Learning and Neuropathology in Wild-Type and Alzheimer's Disease Transgenic Mice

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Effects of Space Radiation on the Function of Human Brain Capillaries and the Blood-brain-barrier: Implications for Neurodegenerative Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Molecular and Cellular Mechanisms of Space Radiation-Induced Changes in Hippocampal-Dependent Behavior

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Combined effects of gamma radiation and high dietary iron on oxidative damage and antioxidant status in rat eyes

Common Item(s)
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Degen - 7: Are there synergistic effects from other spaceflight factors (e.g. altered gravity (µ-gravity), stress, altered immune function, altered circadian rhythms, or other) that modify space radiation-induced degenerative diseases in a clinically significant manner?

Android App Incorporating the PVT to deliver individualized Fatigue Risk Management in Commercial Trucking

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Molecular mechanisms underlying heart failure and arrhythmias in astronauts (1-year NSBRI Postdoctoral Fellowship) (Molecular Arrhythmias-Gershovich/Werhans, Completed)

Common Item(s)
	Risk of Cardiac Rhythm Problems

Mitigating Neurobehavioral Vulnerabilities to Space Radiation (Postdoctoral Fellowship)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Impact of Space Radiation Induced Neuroinflammation on Alzheimer and Parkinson Disease Pathology

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Effect of Space Radiation on degenerative tissue disease, genetic Instability and Oxidative DNA Damage in Ataxia Telangiectasis Deficient Mice

Common Item(s)
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors

Precise Assessment of Prevalence and Progression of Lens Opacities in Astronauts as a Function of Radiation Exposure During Space Flight and Development of Improved Routine Clinical Assessment of Ocular Lens Status

Common Item(s)
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors

Inflammation in the brain after particulate irradiation predisposes the hippocampus to a heightened vulnerability after a secondary insult

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Mechanisms of Ocular Cataracts

Common Item(s)
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors

Mechanisms of high LET radiation induced genomic instability in the CNS - UC Irvine Grant

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

NSCOR: Progressive Alterations of Central Nervous System Structure and Function Are Caused by Charged Particle Radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Neurogenesis and cognition in human apoE transgenic mice following 56Fe radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Speech monitoring of cognitive deficits and stress

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Nutritional countermeasures to ameliorate losses in muscle mass and function

Common Item(s)
	Risk of Inadequate Nutrition

Low Dose Ionizing Radiation and HZE Particle Effects on Adult Hippocampal Neurogenesis: A Sensitive Indicator of CNS Microenvironmental Changes

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Low Dose Radiation Cataract

Common Item(s)
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors

Dose-rate and mixed field effects of protons and HZE nuclei on oxidative injury and stem cell plasticity in the CNS

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Replacement Lighting for Research and Training

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Head-Eye Coordination during Simulated Orbiter Landings (Moore)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Spatial Reorientation of Sensorimotor Balance Control in Altered Gravity (Paloski)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Bed Rest and Immunity

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Sensorimotor adaptation following exposure to ambiguous inertial motion cues (Wood)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Neurochemical and Behavioral Effects of Exposure to Heavy Particles -- NNJ06HD93G

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Mathematical Modeling of Circadian/Performance Countermeasures

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

A Model of Circadian Disruption in the Space Environment

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Optical Computer Recognition of Performance Under Stress

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Development of a User Interface for the PVT SelfTest (PST)

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Echocardiographic Assessment of Cardiovascular Adaptation and Countermeasures in Microgravity (Cardio Adaptation-Thomas, Completed)

Common Item(s)
	Risk of Cardiac Rhythm Problems

Neurovestibular Aspects of Short-radius Artificial Gravity: Toward Comprehensive Counter Measure (Young)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Promoting Sensorimotor Response Generalizability: A Countermeasure to Mitigate Locomotor Dysfunction After Long-Duration Spaceflight (Bloomberg)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Data mining activities for Sensorimotor Discipline (Reschke)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Impact of HZE Particles Exposure on Proliferation and Differentiation of Human Neural System Cells

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Risk of visual impairment and intracranial hypertension after space flight: Evaluation of the role of polymorphism of enzymes involved in one-carbon metabolism [ONE-CARBON METABOLISM/SMITH/COMPLETED]

Common Item(s)
	Risk of Inadequate Nutrition

HZE Radiation Effects On Neuroinflammation: Role Of Cox-2

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Retrospective Analysis of Medication Usage During Long Duration Spaceflight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Inflight pharmacokinetic and pharmacodynamic responses to medications commonly used in spaceflight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Clinical Immunology Study - European Collaboration

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Assessing the Impact of Communication Delay on Performance: An Examination of Autonomous Operations Utilizing the International Space Station

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Cardiac Rhythm Problems
	CV8: Can manifestations of sub-clinical or environmentally induced cardiovascular diseases during spaceflight be predicted?

Common Item(s)
	Risk of Cardiac Rhythm Problems
	CV8: Can manifestations of sub-clinical or environmentally induced cardiovascular diseases during spaceflight be predicted?

Straight Ahead in Microgravity (Clement)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Selection Studies Retrospective

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Concordia: D, Immune and Metabolism

Common Item(s)
	Risk of Inadequate Nutrition

Space Biochemistry Profile

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Adverse Health Event Due to Altered Immune Response
	Risk of Inadequate Nutrition
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.
	IM8: We do not know the influence, direct, or synergistic, on the immune system of other physiological changes associated with spaceflight.
	N15: We need to identify the most important nutritional factors for oxidative damage during spaceflight.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Inadequate Nutrition
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.
	N15: We need to identify the most important nutritional factors for oxidative damage during spaceflight.

Nutrition/Pharm Interactions

Common Item(s)
	Risk of Inadequate Nutrition

Stable Calcium Isotopes in Urine as a Biomarker of Bone Mineral Balance in Spaceflight

Common Item(s)
	Risk of Inadequate Nutrition

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	Sleep Gap 2: We need to understand the contribution of sleep loss, circadian desynchronization, extended wakefulness and work overload, on individual health (physical and behavioral), team functioning, and performance (including operational performance), for spaceflight.

Net Habitable Volume Community of Practice

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Proteomic Profiling of Human Heart Tissue Exposed to Microgravity (Proteomic Heart-Bowles, Completed)

Common Item(s)
	Risk of Cardiac Rhythm Problems

Integrative physiology of VIIP: cardiopulmonary, sleep, and cognitive function assessment during hypercapnic bed rest [Thirty-day CO2 Bedrest/LAURIE/ACTIVE]

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Inadequate Nutrition
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Inner Ear Otoconia Response in Mice to Micro- and Hyper-gravity (Boyle)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Novel Double-Hit Mouse Model to Investigate Oxidative Damage from Radiation/ Hyperoxia Related to Space Exploration - Evaluation of Dietary Flaxseed as Countermeasure

Common Item(s)
	Risk of Inadequate Nutrition
	N15: We need to identify the most important nutritional factors for oxidative damage during spaceflight.

Microgravity Associated Compartmental Equilibration (MACE) [FLUID SHIFTS / DULCHAVSKY / ACTIVE]

Common Item(s)
	Risk of Cardiac Rhythm Problems

Fluid Distribution before, during and after Prolonged Space Flight-NNX13AJ12G [FLUID SHIFTS / HARGENS / ACTIVE]

Common Item(s)
	Risk of Cardiac Rhythm Problems

Distribution of Body Fluids during Long Duration Space Flight and Subsequent Effects on Intraocular Pressure and Vision Disturbance [FLUID SHIFTS / STENGER / ACTIVE]

Common Item(s)
	Risk of Cardiac Rhythm Problems

Targeting NO/IKK Signaling to Counteract Hemodynamic Flow-Dependent Endothelial Dysfunction and Vascular Damage after Space Radiation (Endothelial Dysfunction SR-Natarajan, Active)

Common Item(s)
	Risk of Cardiac Rhythm Problems
	CV8: Can manifestations of sub-clinical or environmentally induced cardiovascular diseases during spaceflight be predicted?

Ultra-Short Light Pulses as Efficient Countermeasures for Circadian Misalignment and Objective Performance and Subjective Alertness Decrements

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

The ISS Dynamic Lighting Schedule: An in-flight lighting countermeasure to facilitate circadian adaptation, improve sleep and enhance alertness and performance on the International Space Station

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Markers of Susceptibility to Neurobehavioral Decrements in Space Flight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Detection and Prevention of Neurobehavioral Vulnerability to Space Radiation II

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Bed Rest as a Spaceflight Analog to Study Neurocognitive Changes: Extent, Longevity, and Neural Bases (Seidler)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Developing Predictive Measures of Sensorimotor Adaptability to Produce Customized Countermeasure Prescriptions (Bloomberg)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Multi-Use Near-Infrared Spectroscopy System for Spaceflight Health Applications

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Potential Subclinical Neurologic Changes in Astronauts due to Repeated Hypobaric Exposures

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Recovery of Functional Performance Following Long Duration Space Flight (Reschke)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Cardiac Rhythm Problems

High LET-radiation induced DNA repair mechanisms in Oligodendrocyte progenitor cells (OPC) in vitro and in vivo - CCSB

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Charged Particle Effects on Neuronal Injury, Plasticity and Neurodegeneration

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Individual Differences in the Neurochemical and Behavioral Response to Exposure to Protons and HZE Particles

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Effects of Space Radiation on Long Term Synaptic Plasticity and Neurogenesis in Normal and Alzheimer's Disease Transgenic Mice

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

The Relation Between Cognitive Injury, Network Stability, and Epigenetic Change Following Exposure to Space Radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Functional immune alterations, latent Herpesvirus reactivation, physiological stress and clinical incidence onboard the International Space Station

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Adverse Health Event Due to Altered Immune Response
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.
	IM8: We do not know the influence, direct, or synergistic, on the immune system of other physiological changes associated with spaceflight.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

New Crop Testing: Nutritional & Organoleptic Analysis

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Association of Diffusion Tensor Imaging Parameters of Optic Tracts and Cerebral White Matter Tracts with Visual Impairment and Structural Changes of the Eyes and Optic Nerves in Long-Duration Microgravity Exposure [DTI/RIASCOS/ACTIVE]

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Common Item(s)
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors

Common Item(s)
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors

Common Item(s)
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Degen - 6: What are the most effective medical or dietary countermeasures to mitigate degenerative tissue risks? Are there common pathways that will benefit multiple tissues?
	Degen - 7: Are there synergistic effects from other spaceflight factors (e.g. altered gravity (µ-gravity), stress, altered immune function, altered circadian rhythms, or other) that modify space radiation-induced degenerative diseases in a clinically significant manner?

Vehicle NHV and Habitability Assessment

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Effects of Long-duration Microgravity on Fine Motor Control Skills

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Sensorimotor Integrative Countermeasure Development - Bedrest (TBD)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Immune Clinical Correlations

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Effects of Long-Duration Spaceflight on Training Retention

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Analog investigation of team resilience over time

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Understanding Key Components of Successful Autonomous Space Missions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Macrocognition in Teams: Examining and Developing Team Cognitive Processes and Products in the Context of Long Duration Exploration Missions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Investigate shifts in team cognitive processes over time (Research Requirements)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)