Short Title:
CVD Rodent ISS
Responsible HRP Element:
Space Radiation
Funding Status:
Planned-Funded - Task expected to be within budget
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Procurement Mechanism(s):
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Aims:
Focus of this research is the evaluation of the effects of the combined exposures (weightlessness plus radiation) on cardiovascular structure and function.
Specific Aims:
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Aim 1: Utilize a ground-based rodent animal model involving hindlimb suspension as a simulation of weightlessness combined with radiation exposures
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Aim 2: Evaluate potential oxidative and inflammatory biomarkers as surrogate endpoints and compare with available human data from ISS missions
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Aim 3: Evaluate effects of combined exposures on disease latency and progression
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Aim 4: Investigate effects of countermeasures for mitigation of the simulated deep space effects
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Aim 5: Validate ground analogs with flight cohorts
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Identification of potential interactions with radiation and weightlessness on cardiovascular disease adverse outcomes; dose thresholds, latency, progression for effects seen; RBEs.
Internal Customers:
None
External Customers:
None