Task Effect of GCR exposure on the functional status of the DNA repair machinery and its contribution to cancer risk
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: GCR, DNA repair and countermeasures
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:

Aim 1. Removed from study.

Aim 2. To test the hypothesis that GCR exposure leads to a chronic DNA damage response in mouse lung and whether this can be abated with a dietary countermeasure, nicotinamide riboside. Sex, dose and radiation quality effects will be investigated.

Aim 3. To determine whether radiogenic tumors display a mutational signature indicative of a decline in the functional status of the DNA repair machinery as reflected in their mutational signature, thus establishing a functional link to tumorigenesis. This aim has been expanded from the original study to include a pilot experiment to determine fixed-dose sex-specific radiation effect ratios (RERs) for lung tumorigenesis. Sex, radiation quality, and countermeasure effects will be investigated.

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Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here!TaskEffect of GCR exposure on the functional status of the DNA repair machinery and its contribution to cancer risk

RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
You are here!TaskEffect of GCR exposure on the functional status of the DNA repair machinery and its contribution to cancer risk

RiskRisk of Radiation Carcinogenesis
You are here!TaskEffect of GCR exposure on the functional status of the DNA repair machinery and its contribution to cancer risk