Task Effect of GCR exposure on the functional status of the DNA repair machinery and its contribution to cancer risk
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: GCR, DNA repair and countermeasures
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:

Aim 1. Removed from study.

Aim 2. To test the hypothesis that GCR exposure leads to a chronic DNA damage response in mouse lung and whether this can be abated with a dietary countermeasure, nicotinamide riboside. Sex, dose and radiation quality effects will be investigated.

Aim 3. To determine whether radiogenic tumors display a mutational signature indicative of a decline in the functional status of the DNA repair machinery as reflected in their mutational signature, thus establishing a functional link to tumorigenesis. This aim has been expanded from the original study to include a pilot experiment to determine fixed-dose sex-specific radiation effect ratios (RERs) for lung tumorigenesis. Sex, radiation quality, and countermeasure effects will be investigated.

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